Enhanced Validation

Anti-HMGCR Antibody

3-hydroxy-3-methylglutaryl-CoA reductase
Recommended Applications
Genetic validation in WB by siRNA knockdown.
Product Description
Monoclonal Antibody against Human HMGCR
Price
$437.00
Product Number
AMAb90619
Unit Size
100 µl
Concentration
Lot dependent
Availability
On Demand
Ships
On Demand
Target protein
3-hydroxy-3-methylglutaryl-CoA reductase
Target gene
HMGCR
Antigen sequence
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence
GAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTT
Epitope
Binds to an epitope located within the peptide sequence TLMETHERGVSIRRQ as determined by overlapping synthetic peptides.
Verified Species Reactivity
Human
Clonality
Monoclonal
Clone ID
CL0260
Isotype
IgG1
Host
Mouse
Buffer
The antibodies are delivered in 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Material Safety Data Sheet
Purification method
Protein A purified
Notes
The antibody solution should be gently mixed before use. Optimal concentrations and conditions for each application should be determined by the user.
Unit Size
100 µl
Current Lot
Produced on demand. Contact support@atlasantibodies.com for more information.
Concentration
[This part should be hidden or updated after call to Current Batch]
Product Data Sheet
Immunohistochemistry (IHC)

Recommended conditions:

Dilution: 1:50 - 1:200

Retrieval method: HIER pH6

Western Blot (WB)

Recommended conditions:

Working concentration: 1 µg/ml

Protocols
Western Blot (WB)

Genetic validation in WB by siRNA knockdown.

Protein Name
3-hydroxy-3-methylglutaryl-CoA reductase
Gene Name
HMGCR
UniProt ID
Gene (Ensembl)
Entrez Gene ID
Shipping
Normally shipped at ambient temperature
Storage
Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Kimbung S, Lettiero B, Feldt M, Bosch A, Borgquist S

High expression of cholesterol biosynthesis genes is associated with resistance to statin treatment and inferior survival in breast cancer

Oncotarget , 2016 Jul 21; 7(37):59640-59651. Epub 2016 Jul 21

PubMed ID: 27458152 DOI: 10.18632/oncotarget.10746

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