Enhanced Validation

Monoclonal Anti-CNP Antibody

2',3'-cyclic nucleotide 3' phosphodiesterase
Recommended Applications
Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.
Product Description
Monoclonal Antibody against Human CNP
Product Number
Unit Size
Lot dependent
5 in Stock
Ready to Ship
Target Protein
2',3'-cyclic nucleotide 3' phosphodiesterase
Target Gene
Belongs to Antibody Panel
Verified Species Reactivity
Human, Mouse, Rat
Interspecies Information

Highest antigen sequence identity to the following orthologs:

Rat ENSRNOG00000017496 (77%)

Mouse ENSMUSG00000006782 (76%)

Clone ID
40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Material Safety Data Sheet
Purification Method
Protein A purified
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Unit Size
100 µl
Current Lot
Produced on demand. Contact support@atlasantibodies.com for more information.
Product Data Sheet
Immunohistochemistry (IHC)

Recommended conditions:

Dilution: 1:10000 - 1:20000

Retrieval method: HIER pH6

Western Blot (WB)

Recommended conditions:

Working concentration: 1 µg/ml

Immunofluorescence in Cell Lines (ICC-IF)

Recommended conditions:

Fixation/Permeabilization: PFA/Triton X-100

Working concentration: 2-10 µg/ml

Immunohistochemistry (IHC)

Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.

Western Blot (WB)

Validated in Western blot using relevant lysates (see Western blot application images above)

Protein Name
2',3'-cyclic nucleotide 3' phosphodiesterase
Gene Name
UniProt ID
Gene (Ensembl)
Entrez Gene ID
Normally shipped at ambient temperature
Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Kurki SN, Uvarov P, Pospelov AS, Trontti K, Hübner AK, Srinivasan R, Watanabe M, Hovatta I, Hübner CA, Kaila K, Virtanen MA

Expression patterns of NKCC1 in neurons and non-neuronal cells during cortico-hippocampal development

Cereb Cortex , 2022 Dec 27; 33(10):5906-5923. Epub 2022 Dec 27

PubMed ID: 36573432 DOI: 10.1093/cercor/bhac470

McNamara NB, Munro DA, Bestard-Cuche N, Uyeda A, Bogie JF, Hoffmann A, Holloway RK, Molina-Gonzalez I, Askew KE, Mitchell S, Mungall W, Dodds M, Dittmayer C, Moss J, Rose J, Szymkowiak S, Amann L, McColl BW, Prinz M, Spires-Jones TL, Stenzel W, Horsburgh K, Hendriks JJ, Pridans C, Muramatsu R, Williams A, Priller J, Miron VE

Microglia regulate central nervous system myelin growth and integrity

Nature , 2022 Dec 14; 613(7942):120-129. Epub 2022 Dec 14

PubMed ID: 36517604 DOI: 10.1038/s41586-022-05534-y

Sadler GL, Lewis KN, Narayana VK, De Souza DP, Mason J, McLean C, Gonsalvez DG, Turner BJ, Barton SK

Lipid Metabolism Is Dysregulated in the Motor Cortex White Matter in Amyotrophic Lateral Sclerosis

Metabolites , 2022 Jun 17; 12(6):554. Epub 2022 Jun 17

PubMed ID: 35736487 DOI: 10.3390/metabo12060554

Neely SA, Williamson JM, Klingseisen A, Zoupi L, Early JJ, Williams A, Lyons DA

New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination

Nat Neurosci , 2022 Feb 14; 25(4):415-420. Epub 2022 Feb 14

PubMed ID: 35165460 DOI: 10.1038/s41593-021-01009-x

Barton SK, Magnani D, James OG, Livesey MR, Selvaraj BT, James OT, Perkins EM, Gregory JM, Cleary E, Ausems CR, Carter RN, Vasistha NA, Zhao C, Burr K, Story D, Cardinali A, Morton NM, Hardingham GE, Wyllie DJ, Chandran S

Transactive response DNA-binding protein-43 proteinopathy in oligodendrocytes revealed using an induced pluripotent stem cell model

Brain Commun , 2021 Oct 26; 3(4):fcab255. Epub 2021 Oct 26

PubMed ID: 35350711 DOI: 10.1093/braincomms/fcab255

Swire M, Assinck P, McNaughton PA, Lyons DA, ffrench-Constant C, Livesey MR

Oligodendrocyte HCN2 Channels Regulate Myelin Sheath Length

J Neurosci , 2021 Sep 22; 41(38):7954-7964

PubMed ID: 34341156 DOI: 10.1523/JNEUROSCI.2463-20.2021

James OG, Selvaraj BT, Magnani D, Burr K, Connick P, Barton SK, Vasistha NA, Hampton DW, Story D, Smigiel R, Ploski R, Brophy PJ, ffrench-Constant C, Lyons DA, Chandran S

iPSC-derived myelinoids to study myelin biology of humans

Dev Cell , 2021 May 3; 56(9):1346-1358.e6

PubMed ID: 33945785 DOI: 10.1016/j.devcel.2021.04.006

Swire M, Ffrench-Constant C

Staining and Quantitative Analysis of Myelinating Oligodendrocytes in the Mouse Grey Matter

Bio Protoc , 2020 Oct 20; 10(20):e3792. Epub 2020 Oct 20

PubMed ID: 33659446 DOI: 10.21769/BioProtoc.3792

Swire M, Kotelevtsev Y, Webb DJ, Lyons DA, ffrench-Constant C

Endothelin signalling mediates experience-dependent myelination in the CNS

eLife , 2019 Oct 28; 8:e49493. Epub 2019 Oct 28

PubMed ID: 31657718 DOI: 10.7554/eLife.49493

Milbreta U, Lin J, Pinese C, Ong W, Chin JS, Shirahama H, Mi R, Williams A, Bechler ME, Wang J, ffrench-Constant C, Hoke A, Chew SY

Scaffold-Mediated Sustained, Non-viral Delivery of miR-219/miR-338 Promotes CNS Remyelination

Mol Ther , 2018 Dec 1; 27(2):411-423. Epub 2018 Dec 1

PubMed ID: 30611662 DOI: 10.1016/j.ymthe.2018.11.016

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