Neural Lineage Development Markers for research

A better comprehension of neuronal lineages is essential to our understanding of the nervous system and how it develops and functions in health and disease.

 

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On this page, you can find our selections of PrecisA MonoclonalsTM and Triple A PolyclonalsTM validated in IHC, ICC-IF and WB for tissue and cell analysis. All antibodies are paired with their specific PrEST AntigensTM.

Primary antibodies in Neuroscience - Full Catalog

Primary antibodies in Neuroscience - Full Catalog


Find the right primary antibody for your research and order here online.

 

Explore full catalog

Lineages are the pathways of development and differentiation of neurons and glial cells in the central nervous system. They are defined by the temporal and spatial relationship between the progenitors, early neuronal precursors, and the mature neurons that result from them. Neuronal lineages can be studied in the context of cell fate determination and the processes of development, such as migration, axon guidance, and synaptogenesis.

Atlas Antibodies manufactures primary polyclonal and monoclonal antibodies targeting relevant markers in the neural lineage development pathways.

Click and find the right primary antibody for your research from the protein list below:

Neuroepithelial Cells

>E-cadherin/CDH1
>C21orf33/HES1
>Nestin
>NOTCH1
>Occludin
>SOX2

Neuroepithelial cells in mouse developing hindbrain. Immunofluorescence of neuroepithelial cells in mouse embryos E6-E14. The anti-SOX2 monoclonal antibody (IgG1, AMAb91307) is visible in green; the anti-L1CAM monoclonal antibody (IgG2a, AMAb91829) is visible in red.

 

Radial Glial Cells

>FABP7/BLBP
>GFAP
>SLC1A3/GLAST
>C21orf33/HES1
>HES5
>PAX6
>SOX2
>Vimentin

Radial glia in developing cerebellum Immunofluorescence of radial glia in mouse embryo E11-E14 and glial cells in adult mouse brain. The anti-VIM polyclonal antibody (HPA001762) is visualized in red; the anti-PAX6 monoclonal antibody (IgG1, AMAb91372) is visible in green.

 

Intermediate Progenitors

>EOMES/TBR2
>HASH1/Ascl1

Immunofluorescence staining of neural progenitors in the developing cerebral cortex of mouse embryos. The anti-SOX2 monoclonal antibody (IgG1, AMAb91307) is visible in green; the anti-MSI1 (Musashi-1) polyclonal antibody (HPA074923) is visible in red. Nuclei are stained with DAPI, in blue.

 

Restricted Progenitors

Immature neuronal cells

>DCX
>TUBB3
>Nestin
>NeuroD1
>TBR1

Immature glial cells

>PDGF receptor alpha
>NG2

Immunofluorescence staining of immature neurons in the developing telencephalon/cerebral cortex of mouse embryos E6- E14. The anti-TUBB3 monoclonal antibody (IgG1, AMAb91394) is visible in green; the anti-TBR1 polyclonal antibody (HPA078644) is visible in red.

 

Differentiated Neurons

>RBFOX3/NeuN
>MAP2
>NEFM medium
>NEFM heavy
>synaptophysin
>PSD95/DLG4

Immunofluorescence staining of differentiated neurons in the adult mouse cerebral cortex. (Left) The anti-MAP2 polyclonal antibody (HPA012828) is visible in green; the anti-RBFOX3 monoclonal (IgG2b, AMAb91748) is visible in red, and the anti-NEFM monoclonal (IgG1, AMAb91027) in blue. (Right) The anti-VGluT1 monoclonal antibody (IgG2b, AMAb91041) is visible in green; the anti-GAD1 monoclonal (IgG2a, AMAb91076) is visible in red, and the anti-ChAT monoclonal (IgG1, AMAb91129) in blue.

 

Glutamatergic neurons

>SLC17A7/VGLUT1
>VGLUT2
>GRIN1/NMDAR1
>GRIN2B/NMDAR2B
>GLS

 

Gabaergic neurons

>SLC6A1/GAT1
>GABBR1
>GABBR2
>GAD2/GAD65
>GAD1/GAD67

 

Dopaminergic neurons

>TH
>FOXA2
>NR4A2/Nurr1
>LMX1B

 

Serotonergic neurons

>SLC6A4/SERT1
>TPH1
>TPH2

 

Cholinergic neurons

>CHAT
>ACHE

 

Motor neurons

>Isl1
>Isl2
>Olig2

 

Differentiated Glial Cells

Astrocytes type 2

>AQP4
>GFAP
>SLC1A3/GLAST
>SLC1A2/GLT-1
>S100 beta
>ALDH1L1
>VIMENTIN

 

Mature Oligodendrocytes

>MBP
>MOG
>olig 2
>olig 3
>SOX10

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