Centriolar Satellite Markers

The centrosome, a pivotal cellular organelle, stands as the primary microtubule-organizing center within the cell. It encompasses centrioles, structures crucial for the formation of spindle fibers during cell division, as well as a concentrated mass of proteins known as centriolar satellites or peri-centriolar material.

Centriolar satellites play a pivotal role in centrosome function and regulation, influencing processes such as microtubule organization, ciliary transport, and cell cycle progression. Understanding the dynamics and components of centriolar satellites is integral to unraveling the intricacies of cellular organization and function.

Key markers include:

PCM1 (Pericentriolar Material 1): A well-established marker for centriolar satellites, PCM1 is involved in the recruitment and organization of proteins around the centrosome.

Cep290 (Centrosomal Protein 290): Essential for ciliary function, Cep290 is associated with centriolar satellites and is implicated in various cellular processes.

OFD1 (Oral-Facial-Digital Syndrome 1): OFD1 is not only a centriolar satellite marker but also plays a crucial role in centriole elongation and docking.