The Human Protein Atlas
The Human Protein Atlas is a Swedish-based program initiated in 2003 with the aim to map all the human proteins in cells, tissues, and organs using an integration of various omics technologies, including antibody-based imaging, mass spectrometry-based proteomics, transcriptomics, and systems biology. All the data in the knowledge resource is open access to allow scientists both in academia and industry to freely access the data for exploration of the human proteome.
The Human Protein Atlas program has already contributed to several thousands of publications in the field of human biology and disease and it is selected by the organization ELIXIR (www.elixir-europe.org) as a European core resource due to its fundamental importance for a wider life science community. The Human Protein Atlas consortium is mainly funded by the Knut and Alice Wallenberg Foundation.
The Human Protein Atlas consists of twelve separate sections, each focusing on a particular aspect of the genome-wide analysis of the human proteins:
Atlas Antibodies and the Human Protein Atlas
Atlas Antibodies was founded in 2006 by researchers from the Human Protein Atlas (HPA)
As part of creating the human protein expression map, researchers from the Human Protein Atlas project developed highly specific polyclonal antibodies targeting all protein-coding human genes.
Atlas Antibodies manufactures and commercializes Triple A Polyclonals, the polyclonal antibodies used to build the Human Protein Atlas database.
All Triple A Polyclonals are carefully designed and manufactured to achieve the very highest level of specificity, reproducibility, and versatility. For each antibody, you have free access to over 500 IHC staining images of all major human organs and cancer types.
12 ways to explore the human proteome
The Human Protein Atlas consists of twelve separate sections, each focusing on a particular aspect of the genome-wide analysis of the human proteins:
- The Tissue section shows the distribution of the proteins across all major tissues and organs in the human body
- The Brain section explores the distribution of proteins in various regions of the mammalian brain
- The Single Cell Type section shows expression of protein-coding genes in single human cell types based on scRNA-seq
- The Tissue Cell Type section shows expression of protein-coding genes in human cell types based on bulk RNAseq data
- The Pathology section shows the impact of protein levels on the survival of patients with cancer
- The Disease Blood Atlas section shows protein levels in blood in patients with different diseases and protein panels used for disease prediction
- The Immune Cell section shows the expression of protein-coding genes in immune cell types
- The Blood Protein section describes proteins detected in blood and proteins secreted by human tissues
- The Subcellular section shows the subcellular localization of proteins in single cells
- The Cell Line section shows expression of protein-coding genes in human cell lines
- The Structure section shows experimental and predicted 3D structures of proteins including antigen sites and population- and clinical variants
- The Interaction section explores the expression and features of protein-coding genes in the context of protein-protein and metabolic interaction networks
The purpose of the dictionary is to facilitate the interpretation and use of the image-based data available in the Human Protein Atlas but also to serve as a tool for training and understanding histology, pathology, and cell biology. The dictionary contains three main parts: normal tissue histology, pathology, and cell structure.