The Brain Atlas

The brain is our central computer that controls most of the body's functions. The Brain Atlas section of the Human Protein Atlas explores the protein expression in the mammalian brain by integration of data from human, pig and mouse. 

 

An open-access map of the mammalian brain

The Brain Atlas, part of the Human Protein Altas, is an open-access database that explores the protein expression in the mammalian brain: human, pig and mouse. This is achieved through visualization and integration of data from the three species together with transcriptomics data. Antibody-based protein localization data is presented for selected protein targets in human and mouse brain.

The Brain Atlas
The ten anatomical regions in the Brain Atlas section of the Human Protein Atlas. Image from the Human Protein Atlas

In the Brain Atlas, you can explore which proteins are expressed in a particular part of the brain or where in the brain your protein of interest is expressed. Each mammalian brain is divided into 10 defined anatomical regions. The regional expression protein profile includes 1,710 human brain samples, 119 pig brain samples and 67 mouse brain samples. 

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Start exploring the Brain Atlas section of the Human Protein Atlas.

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Antibody stainings of entire mouse brain sections

The basic architecture and organization of the brain, as well as gene expression and protein sequences, are largely preserved throughout mammalian evolution. The complexity of the human brain, an organ with many structures and cell types present both in the cortical and subcortical areas, makes the protein expression profiles and classification challenges. For this reason, a smaller brain, such as the mouse brain, is a useful model to study the mammalian nervous system using the same antibodies as for the human brain. The Brain Atlas, presents antibody stainings on consecutive sections of the entire mouse brain.

The protein expression profiles in brain tissues for each of the genes are available on the Brain Atlas section of the Human Protein Atlas. The mouse stainings are visible in the Primary Mouse Data section.  An example for the MAP2 gene is shown below.

Image from the MAP2 gene as shown on the Human Protein Atlas.
Image from the MAP2 gene page as shown on the Human Protein Atlas. The Mouse Brain subsection of the MAP2 database entry shows MAP2 protein expression profiles in the mouse brain. (https://www.proteinatlas.org/ENSG00000078018-MAP2/brain)

The antibodies used for to create the stainings in the Brain Atlas, are manufactured and made available to fellow researchers by us at Atlas Antibodies as Triple A Polyclonals.

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Discover Triple A Polyclonals

The antibodies used in the Human Protein Atlas, are available from Atlas Antibodies as Triple A Polyclonals. For each antibody you have access to staining images and characterization data from 44 normal tissues and the 20 most common cancers on the Human Protein Atlas.

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Human Brain Poster

Human Brain Poster

Get a free poster presenting the Brain Atlas. 

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