The Blood Atlas
Significant advances in our understanding of the immune system have been made in recent decades, but we still have much to learn, particularly about the similarities and differences between different immune cells with respect to genomics, proteomics, and transcriptomics.
An open-access map of the human blood proteins and the secretome
The Blood Atlas, part of the Human Protein Atlas, is an open-access database focusing on the expression levels of all human protein-coding genes in major blood immune cell populations, as well as proteins actively secreted to blood. The Blood Atlas contains single cell type information of genome-wide RNA expression profiles of human protein-coding genes covering various B- and T-cells, monocytes, granulocytes, and dendritic cells.
The single-cell transcriptomics analysis covers 18 cell types isolated with cell sorting followed by RNA-Seq analysis. In addition, an analysis of the “human secretome” is presented including annotation of the genes predicted to be actively secreted to human blood, as well as the annotation of proteins predicted to be secreted to other parts of the human body, such as the gastric tract and local compartments. An analysis of the proteins detected in human blood is presented with an estimation of the respective protein concentrations determined either with mass spectrometry-based proteomics or antibody-based immune assays.
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