The Human Protein Atlas

The Human Protein Atlas is a unique world-leading effort to map all the human proteins in cells, tissues, and organs in the human body using antibody-based imaging, mass spectrometry-based proteomics, transcriptomics, and systems biology. 

Atlas Antibodies and the Human Protein Atlas

Atlas Antibodies was founded in 2006 by researchers from the Human Protein Atlas.

As part of creating the human protein expression map, researchers from the Human Protein Atlas project developed highly specific polyclonal antibodies targeting all protein-coding human genes. 

Atlas Antibodies manufacture and commercialize these polyclonal antibodies as Triple A Polyclonals.

All Triple A Polyclonals are carefully designed and manufactured to achieve the very highest level of specificity, reproducibility, and versatility. For each antibody, you have free access to over 500 IHC staining images of all major human organs and cancer types. 

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New Triple A Polyclonals - Human Protein Atlas release 2023

The Human Protein Atlas releases a new version of its resource each year with expanded data. 

Triple A Polyclonals for tissue and cell analysis.

The products listed in the brochure are a selection of TripleA Polyclonals released this year. 

Additionally, polyclonal antibodies offer robustness and versatility, allowing you to explore the heterogeneity of tissues, organs, and cells, leading to a deeper understanding of human biology and the development of targeted therapies for different diseases.

👉 Here you can find the full list of Triple A Polyclonals released in HPA version 23.

 

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12 ways to explore the human proteome

The Tissue Atlas

The tissue-based map of the human proteome

Expression profiles of human genes at the mRNA and protein levels. Explore immunohistochemical stainings from 44 human tissues using our Triple A Polyclonals. 

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The Subcellular Atlas

The map of the human proteome at subcellular level

High-resolution insights into the distribution of the proteins within 35 organelles and fine subcellular structures of the human cells using our Triple A Polyclonals.

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The Brain Atlas

The protein profiles of the mammalian brain

Comprehensive spatial protein profiling of the mammalian brains - human, pigs, and mice - using our Triple A Polyclonals.

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The Pathology Atlas

The protein expression profiles of human cancers

The Pathology Atlas provides information on the role of genes, mRNA, and protein expression from 17 forms of human cancer and tissue using our Triple A Polyclonals.

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The Blood Protein Atlas

The proteins in the human blood

Estimated plasma concentrations of proteins in the human blood and proteins actively secreted to blood using our Triple A Polyclonals.

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The Cell Line Atlas

The protein expression profiles in human cell lines

The Cell Line section contains information on genome-wide RNA expression profiles of human protein-coding genes in 69 human cell lines.

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The Single Cell Type Atlas

The protein expression profiles in single-cell types

Information based on single-cell RNA sequencing data from 25 human tissues and peripheral blood mononuclear cells, together with IHC tissue staining visualizing the spatial profile of the corresponding protein.

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The Tissue Cell Type Atlas

The cell-type specificity of genes within human tissues

Cell type expression specificity predictions for all human protein-coding genes, to learn which genes have predicted enriched expression in cell types, across multiple human tissues.

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The Immune Cell Atlas

The protein expression profile in human immune cells

Expression profiles of human protein-coding genes in B- and T-cells, monocytes, granulocytes, and dendritic cells to learn which genes are enriched in a particular immune cell type or have a similar expression profile across the immune cells.

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The Metabolic Atlas

The expression profiles of enzymes involved in human metabolism

Tissue-specific gene expression and exploration of protein functions in the human metabolic network. Over 120 metabolic pathway maps facilitate the visualization of each protein's participation in different metabolic processes.

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The Human Disease Blood Atlas

The disease section

The Human Disease Blood Atlas contains information on protein levels in blood in patients with different diseases and highlights proteins associated with these diseases Protein profiles have been quantified across 12 major cancer types. 

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The 3D structure section

The three-dimensional structure of human proteins.

The predicted 3D structure from the AlphaFold Protein Structure Database project is shown together with experimentally determined structures from the Protein Data Bank. All antigens with known sequences have been mapped and can be displayed on the protein structures.

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The Human Protein Atlas Dictionary

The purpose of the dictionary is to facilitate the interpretation and use of the image-based data available in the Human Protein Atlas, but also to serve as a tool for training and understanding histology, pathology, and cell biology. The dictionary contains three main parts: normal tissue histology, pathology, and cell structure. 

 

The aim of this section is to educate readers about the histology of normal and cancer tissues, which provides important and basic information for our understanding of biology and medicine. The dictionary covering cell structure is built around antibody-based stainings of proteins in cell lines using immunofluorescence and confocal microscopy. 

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Webinars

Learn more about the Human Protein Atlas and the research behind the atlas in our webinar series. 

Go to webinars