Anti-TTR Antibody

transthyretin
Recommended Applications
Product Description
Polyclonal Antibody against Human TTR
Alternative Gene Names
CTS, CTS1, HsT2651, PALB
Price
$450.00
Product Number
HPA002550
Unit Size
100 µl
Concentration
Lot dependent
Availability
>10 in Stock
Ships
Ready to Ship
Target Protein
transthyretin
Target Gene
TTR
Antigen Sequence
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence
GTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
Verified Species Reactivity
Human
Interspecies Information

Highest antigen sequence identity to the following orthologs:

Rat ENSRNOG00000016275 (83%)

Mouse ENSMUSG00000061808 (81%)

Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Buffer
40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Material Safety Data Sheet
Purification Method
Affinity purified using the PrEST antigen as affinity ligand
Notes
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Unit Size
100 µl
Current Lot
Produced on demand. Contact support@atlasantibodies.com for more information.
Concentration
Product Data Sheet
Immunohistochemistry (IHC)

Recommended conditions:

Dilution: 1:1000 - 1:2500

Retrieval method: HIER pH6

Western Blot (WB)

Recommended conditions:

Working concentration: 0.04-0.4 µg/ml

Immunofluorescence in Cell Lines (ICC-IF)

Recommended conditions:

Fixation/Permeabilization: PFA/Triton X-100

Working concentration: 0.25-2 µg/ml

Protocols
Western Blot (WB)

Validated in Western blot using relevant lysates (see Western blot application images above)

Protein Name
transthyretin
Gene Name
TTR
Alternative Gene Names
CTS, CTS1, HsT2651, PALB
UniProt ID
Gene (Ensembl)
Entrez Gene ID
Shipping
Normally shipped at ambient temperature
Storage
Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Human Protein Atlas

This antibody has been used for staining of 44 normal human tissue samples as well as human cancer samples covering the 20 most common cancer types and up to 12 patients for each cancer type. The results are part of an ongoing effort to map the human proteome using antibodies.

All characterization data for ENSG00000118271 on the Human Protein Atlas

Galant NJ, Bugyei-Twum A, Rakhit R, Walsh P, Sharpe S, Arslan PE, Westermark P, Higaki JN, Torres R, Tapia J, Chakrabartty A

Substoichiometric inhibition of transthyretin misfolding by immune-targeting sparsely populated misfolding intermediates: a potential diagnostic and therapeutic for TTR amyloidoses

Sci Rep , 2016 Apr 28; 6:25080. Epub 2016 Apr 28

PubMed ID: 27122057 DOI: 10.1038/srep25080

Liu T, Zhang B, Jin X, Wang W, Lee J, Li J, Yuan H, Cheng X

Ophthalmic manifestations in a Chinese family with familial amyloid polyneuropathy due to a TTR Gly83Arg mutation

Eye (Lond) , 2014 Jan; 28(1):26-33. Epub 2013 Oct 11

PubMed ID: 24113303 DOI: 10.1038/eye.2013.217

Kato BS, Nicholson G, Neiman M, Rantalainen M, Holmes CC, Barrett A, Uhlén M, Nilsson P, Spector TD, Schwenk JM

Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model

Proteome Sci , 2011 Nov 17; 9:73. Epub 2011 Nov 17

PubMed ID: 22093360 DOI: 10.1186/1477-5956-9-73

Noborn F, O'Callaghan P, Hermansson E, Zhang X, Ancsin JB, Damas AM, Dacklin I, Presto J, Johansson J, Saraiva MJ, Lundgren E, Kisilevsky R, Westermark P, Li JP

Heparan sulfate/heparin promotes transthyretin fibrillization through selective binding to a basic motif in the protein.

Proc Natl Acad Sci U S A , 2011 Apr 5; 108(14):5584-9. Epub 2011 Mar 21

PubMed ID: 21422279 DOI: 10.1073/pnas.1101194108

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Alternative Antibodies
Corresponding Antigens

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