Polyclonal Anti-TMPRSS2 Antibody
Highest antigen sequence identity to the following orthologs:
Mouse ENSMUSG00000000385 (66%)
Rat ENSRNOG00000001976 (66%)
Dilution: 1:200 - 1:500
Retrieval method: HIER pH6
Working concentration: 0.04-0.4 µg/ml
Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.
Validated in Western blot using relevant lysates (see Western blot application images above)
This antibody has been used for staining of 44 normal human tissue samples as well as human cancer samples covering the 20 most common cancer types and up to 12 patients for each cancer type. The results are part of an ongoing effort to map the human proteome using antibodies.
All characterization data for ENSG00000184012 on the Human Protein Atlas
Impact of TMPRSS2 Expression, Mutation Prognostics, and Small Molecule (CD, AD, TQ, and TQFL12) Inhibition on Pan-Cancer Tumors and Susceptibility to SARS-CoV-2
Molecules , 2022 Nov 1; 27(21):7413. Epub 2022 Nov 1
Expanded ACE2 dependencies of diverse SARS-like coronavirus receptor binding domains
PLoS Biol , 2022 Jul 27; 20(7):e3001738. Epub 2022 Jul 27
Angiotensin‐converting enzyme 2 and transmembrane protease serine 2 in female and male patients with end‐stage kidney disease
Eur J Clin Invest , 2022 Apr 9; 52(8):e13786. Epub 2022 Apr 9
Systematic Investigation of SARS-CoV-2 Receptor Protein Distribution along Viral Entry Routes in Humans
Respiration , . Epub 2022 Jan 17
SARS‐CoV‐2 Alpha, Beta, and Delta variants display enhanced Spike‐mediated syncytia formation
EMBO J , . Epub 2021 Oct 25
Viral S protein histochemistry reveals few potential SARS-CoV-2 entry sites in human ocular tissues
Sci Rep , 2021 Sep 27; 11:19140. Epub 2021 Sep 27
SARS-COV-2 spike binding to ACE2 in living cells monitored by TR-FRET
Cell Chem Biol , . Epub 2021 Jul 2
Clinical and in Vitro Evidence against Placenta Infection at Term by Severe Acute Respiratory Syndrome Coronavirus 2
Am J Pathol , 2021 Jun 8; 191(9):1610-1623. Epub 2021 Jun 8
COVID-19 during Pregnancy: Clinical and In Vitro Evidence against Placenta Infection at Term by SARS-CoV-2
Am J Pathol , . Epub 2021 Jun 8
Elevation in viral entry genes and innate immunity compromise underlying increased infectivity and severity of COVID-19 in cancer patients
Sci Rep , 2021 Feb 25; 11:4533. Epub 2021 Feb 25
Tropism of Severe Acute Respiratory Syndrome Coronavirus 2 for Barrett’s Esophagus May Increase Susceptibility to Developing Coronavirus Disease 2019
Gastroenterology , . Epub 2021 Jan 20
Syncytia formation by SARS‐CoV‐2‐infected cells
EMBO J , . Epub 2020 Nov 4
SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells
Cell Metab , 2020 Nov 13; 32(6):1028-1040.e4. Epub 2020 Nov 13
Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue
Eur Respir J , 2020 Sep 3; 56(3):2001123. Epub 2020 Sep 3
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