Highest antigen sequence identity to the following orthologs:
Rat ENSRNOG00000000394 (55%)
Mouse ENSMUSG00000020077 (53%)
Dilution: 1:1000 - 1:2500
Retrieval method: HIER pH6
Working concentration: 0.04-0.4 µg/ml
Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.
Orthogonal validation of protein expression using WB by comparison to RNA-seq data of corresponding target in high and low expression cell lines.
This antibody has been used for staining of 44 normal human tissue samples as well as human cancer samples covering the 20 most common cancer types and up to 12 patients for each cancer type. The results are part of an ongoing effort to map the human proteome using antibodies.
Proteoglycan serglycin promotes non-small cell lung cancer cell migration through the interaction of its glycosaminoglycans with CD44
J Biomed Sci , 2020 Jan 2; 27:2. Epub 2020 Jan 2
Serglycin as a potential biomarker for glioma: association of serglycin expression, extent of mast cell recruitment and glioblastoma progression
Oncotarget , 2017 Mar 1; 8(15):24815-24827. Epub 2017 Mar 1
Serglycin in tumor microenvironment promotes non-small cell lung cancer aggressiveness in a CD44-dependent manner
Oncogene , 2016 Nov 7; 36(17):2457-2471. Epub 2016 Nov 7
Serglycin in Quiescent and Proliferating Primary Endothelial Cells
PLOS ONE , December 22, 2015
Serglycin Proteoglycan Is Required for Multiple Myeloma Cell Adhesion, in Vivo Growth, and Vascularization
J Biol Chem , 2014 Feb 28; 289(9):5499-5509. Epub 2014 Jan 8
Monocyte-to-macrophage differentiation: synthesis and secretion of a complex extracellular matrix.
J Biol Chem , 2012 Apr 20; 287(17):14122-35. Epub 2012 Feb 20
From gene expression analysis to tissue microarrays: a rational approach to identify therapeutic and diagnostic targets in lymphoid malignancies.
Mol Cell Proteomics , 2006 Jun; 5(6):1072-81. Epub 2006 Mar 8
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