Highest antigen sequence identity to the following orthologs:
Rat ENSRNOG00000030034 (82%)
Mouse ENSMUSG00000063632 (82%)
Dilution: 1:200 - 1:500
Retrieval method: HIER pH6
Working concentration: 0.04-0.4 µg/ml
Validated in Western blot using relevant lysates (see Western blot application images above)
This antibody has been used for staining of 44 normal human tissue samples as well as human cancer samples covering the 20 most common cancer types and up to 12 patients for each cancer type. The results are part of an ongoing effort to map the human proteome using antibodies.
Clinicopathological features and prognostic value of SOX11 in childhood acute lymphoblastic leukemia
Sci Rep , 2020 Feb 6; 10:2043. Epub 2020 Feb 6
Diagnostic accuracy of SOX11 immunohistochemistry in mantle cell lymphoma: A meta-analysis
PLoS One , 2019 Nov 12; 14(11):e0225096. Epub 2019 Nov 12
SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair
Nat Commun , 2019 Sep 6; 10:4042. Epub 2019 Sep 6
SOX11: friend or foe in tumor prevention and carcinogenesis?
Ther Adv Med Oncol , 2019 Jun 3; 11:1758835919853449. Epub 2019 Jun 3
Impact of Sox11 over-expression in Ba/F3 cells
Haematologica , 2018 Dec; 103(12):e594-e597
Persistence of a t(11;14)‐positive clone in a patient with mantle cell lymphoma for 20 years
Clin Case Rep , 2017 Mar 2; 5(4):477-481. Epub 2017 Mar 2
Plasma cell and terminal B-cell differentiation in mantle cell lymphoma mainly occur in the SOX11-negative subtype
Modern Pathology , September 11, 2015
Tripeptidyl Peptidase II Mediates Levels of Nuclear Phosphorylated ERK1 and ERK2
Mol Cell Proteomics , 2015 Jun 3; 14(8):2177-2193. Epub 2015 Jun 3
High resolution Chromatin Immunoprecipitation (ChIP) sequencing reveals novel bindings targets and prognostic role for SOX11 in Mantle cell lymphoma
Oncogene , 2015 Mar 5; 34(10):1231-1240. Epub 2014 Mar 31
The clinical role of epithelial-mesenchymal transition and stem cell markers in advanced-stage ovarian serous carcinoma effusions.
Hum Pathol , 2015 Jan; 46(1):1-8
The expression of SOX11, cyclin D1, cyclin D2, and cyclin D3 in B-cell lymphocytic proliferative diseases.
Med Oncol , 2012 Jun; 29(2):1190-6. Epub 2011 Apr 9
Prognostic role of SOX11 in a population-based cohort of mantle cell lymphoma.
Blood , 2012 May 3; 119(18):4215-23. Epub 2012 Mar 19
In situ mantle cell lymphoma: clinical implications of an incidental finding with indolent clinical behavior.
Haematologica , 2012 Feb; 97(2):270-8. Epub 2011 Nov 4
The tumour suppressor SOX11 is associated with improved survival among high grade epithelial ovarian cancers and is regulated by reversible promoter methylation.
BMC Cancer , 2011 Sep 24; 11:405. Epub 2011 Sep 24
Small cell variant of mantle cell lymphoma is an indolent lymphoma characterized by bone marrow involvement, splenomegaly, and a low Ki-67 index.
Cancer Sci , 2011 Sep; 102(9):1734-41. Epub 2011 Jun 23
Indolent mantle cell leukemia: a clinicopathological variant characterized by isolated lymphocytosis, interstitial bone marrow involvement, kappa light chain restriction, and good prognosis.
Haematologica , 2011 Aug; 96(8):1121-7. Epub 2011 Apr 20
Gene Expression Profiling and Chromatin Immunoprecipitation Identify DBN1, SETMAR and HIG2 as Direct Targets of SOX11 in Mantle Cell Lymphoma
PLoS One , 2010 Nov 22; 5(11):e14085. Epub 2010 Nov 22
SOX11 expression correlates to promoter methylation and regulates tumor growth in hematopoietic malignancies.
Mol Cancer , 2010 Jul 12; 9:187. Epub 2010 Jul 12
Wilms Tumor Chromatin Profiles Highlight Stem Cell Properties and a Renal Developmental Network
Cell Stem Cell , 2010 Jun 4; 6(6):591-602
Genomic and gene expression profiling defines indolent forms of mantle cell lymphoma.
Cancer Res , 2010 Feb 15; 70(4):1408-18. Epub 2010 Feb 2
Nuclear expression of sox11 is highly associated with mantle cell lymphoma but is independent of t(11;14)(q13;q32) in non-mantle cell B-cell neoplasms.
Mod Pathol , 2010 Jan; 23(1):105-12. Epub 2009 Oct 2
SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype.
Haematologica , 2009 Nov; 94(11):1555-62
Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma.
Haematologica , 2009 Nov; 94(11):1563-8
The subcellular Sox11 distribution pattern identifies subsets of mantle cell lymphoma: correlation to overall survival.
Br J Haematol , 2008 Oct; 143(2):248-52. Epub 2008 Aug 20
Nuclear expression of the non B-cell lineage Sox11 transcription factor identifies mantle cell lymphoma.
Blood , 2008 Jan 15; 111(2):800-5. Epub 2007 Oct 12
From gene expression analysis to tissue microarrays: a rational approach to identify therapeutic and diagnostic targets in lymphoid malignancies.
Mol Cell Proteomics , 2006 Jun; 5(6):1072-81. Epub 2006 Mar 8
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