Highest antigen sequence identity to the following orthologs:
Rat ENSRNOG00000016628 (96%)
Mouse ENSMUSG00000021337 (96%)
Dilution: 1:500 - 1:1000
Retrieval method: HIER pH6
Working concentration: 0.04-0.4 µg/ml
Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.
Validated in Western blot using relevant lysates (see Western blot application images above)
This antibody has been used for staining of 44 normal human tissue samples as well as human cancer samples covering the 20 most common cancer types and up to 12 patients for each cancer type. The results are part of an ongoing effort to map the human proteome using antibodies.
Immature excitatory neurons develop during adolescence in the human amygdala
Nat Commun , 2019 Jun 21; 10:2748. Epub 2019 Jun 21
Ferret brain possesses young interneuron collections equivalent to human postnatal migratory streams
J Comp Neurol , 2019 May 15; 527(17):2843-2859. Epub 2019 May 15
Secretagogin is increased in plasma from type 2 diabetes patients and potentially reflects stress and islet dysfunction
PLoS One , 2018 Apr 27; 13(4):e0196601. Epub 2018 Apr 27
Deafferented Adult Rod Bipolar Cells Create New Synapses with Photoreceptors to Restore Vision
J Neurosci , 2017 Apr 26; 37(17):4635-4644
Calcium Binding and Disulfide Bonds Regulate the Stability of Secretagogin towards Thermal and Urea Denaturation
PLoS One , 2016 Nov 3; 11(11):e0165709. Epub 2016 Nov 3
Neuronal calcium-binding proteins 1/2 localize to dorsal root ganglia and excitatory spinal neurons and are regulated by nerve injury
Proc Natl Acad Sci U S A , 2014 Mar 25; 111(12):E1149-E1158. Epub 2014 Mar 10
Distribution of secretagogin-containing neurons in the basal forebrain of mice, with special reference to the cholinergic corticopetal system
Brain Res Bull , 2013 May; 94:1-8. Epub 2013 Jan 29
Novel pancreatic beta cell-specific proteins: antibody-based proteomics for identification of new biomarker candidates.
J Proteomics , 2012 May 17; 75(9):2611-20. Epub 2012 Mar 21
Clusters of secretagogin-expressing neurons in the aged human olfactory tract lack terminal differentiation.
Proc Natl Acad Sci U S A , 2012 Apr 17; 109(16):6259-64. Epub 2012 Apr 2
The renaissance of Ca2+-binding proteins in the nervous system: secretagogin takes center stage.
Cell Signal , 2012 Feb; 24(2):378-87. Epub 2011 Oct 1
Secretagogin is a Ca2+-binding protein identifying prospective extended amygdala neurons in the developing mammalian telencephalon
Eur J Neurosci , 2010 Jun; 31(12):2166-2177. Epub 2010 Jun 7
Secretagogin is a Ca2+-binding protein specifying subpopulations of telencephalic neurons
Proc Natl Acad Sci U S A , 2009 Dec 29; 106(52):22492-22497. Epub 2009 Dec 16
Tissue Profiling of the Mammalian Central Nervous System Using Human Antibody-based Proteomics
Mol Cell Proteomics , 2009 Jul; 8(7):1612-1622. Epub 2009 Apr 7
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