Highest antigen sequence identity to the following orthologs:
Mouse ENSMUSG00000039153 (100%)
Rat ENSRNOG00000020193 (81%)
Dilution: 1:200 - 1:500
Retrieval method: HIER pH6
Working concentration: 0.04-0.4 µg/ml
Fixation/Permeabilization: PFA/Triton X-100
Working concentration: 0.25-2 µg/ml
Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.
Genetic validation in WB by siRNA knockdown.
This antibody has been used for staining of 44 normal human tissue samples as well as human cancer samples covering the 20 most common cancer types and up to 12 patients for each cancer type. The results are part of an ongoing effort to map the human proteome using antibodies.
Mandibular dysmorphology due to abnormal embryonic osteogenesis in FGFR2-related craniosynostosis mice
Dis Model Mech , 2019 May 30; 12(5):dmm038513. Epub 2019 May 30
Midface and upper airway dysgenesis in FGFR2-related craniosynostosis involves multiple tissue-specific and cell cycle effects
Development , 2018 Oct 5; 145(19):dev166488. Epub 2018 Oct 5
C-type natriuretic peptide analog treatment of craniosynostosis in a Crouzon syndrome mouse model
PLoS One , 2018 Jul 26; 13(7):e0201492. Epub 2018 Jul 26
Time-dependent regulation of morphological changes and cartilage differentiation markers in the mouse pubic symphysis during pregnancy and postpartum recovery
PLoS One , 2018 Apr 5; 13(4):e0195304. Epub 2018 Apr 5
Targeting the gut microbiome to treat the osteoarthritis of obesity
JCI Insight , 2018 Apr 19; 3(8):e95997. Epub 2018 Apr 19
Runx2 contributes to the regenerative potential of the mammary epithelium
Sci Rep , 2015 Oct 22; 5:15658. Epub 2015 Oct 22
BCL11B expression in intramembranous osteogenesis during murine craniofacial suture development
Gene Expr Patterns , 2015/01/01; 17(1):16-25. Epub 2014 Dec 12
RUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary gland
Dis Model Mech , 2014 May; 7(5):525-534. Epub 2014 Mar 13
From shape to cells: mouse models reveal mechanisms altering palate development in Apert syndrome
Dis Model Mech , 2013 May; 6(3):768-779. Epub 2013 Mar 8
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