Highest antigen sequence identity to the following orthologs:
Mouse ENSMUSG00000042396 (79%)
Rat ENSRNOG00000005710 (71%)
Dilution: 1:200 - 1:500
Retrieval method: HIER pH6
Fixation/Permeabilization: PFA/Triton X-100
Working concentration: 0.25-2 µg/ml
This antibody has been used for staining of 44 normal human tissue samples as well as human cancer samples covering the 20 most common cancer types and up to 12 patients for each cancer type. The results are part of an ongoing effort to map the human proteome using antibodies.
ZCCHC8, the nuclear exosome targeting component, is mutated in familial pulmonary fibrosis and is required for telomerase RNA maturation
Genes Dev , 2019 Oct 1; 33(19-20):1381-1396
The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs
Nat Commun , 2019 Jul 29; 10:3393. Epub 2019 Jul 29
P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress
Mol Cell , 2019 Apr 18; 74(2):254-267.e10
The RNA exosome contributes to gene expression regulation during stem cell differentiation
Nucleic Acids Res , 2018 Sep 13; 46(21):11502-11513. Epub 2018 Sep 13
The RNA exosome syncs IAV-RNAPII transcription to promote viral ribogenesis and infectivity.
Cell , 2017 May 4; 169(4):679-692.e14
Structure of the RBM7–ZCCHC8 core of the NEXT complex reveals connections to splicing factors
Nat Commun , 2016 Dec 1; 7:13573. Epub 2016 Dec 1
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