Highest antigen sequence identity to the following orthologs:
Mouse ENSMUSG00000028591 (55%)
Rat ENSRNOG00000037035 (55%)
Dilution: 1:200 - 1:500
Retrieval method: HIER pH6
Working concentration: 0.04-0.4 µg/ml
Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.
Orthogonal validation of protein expression using WB by comparison to RNA-seq data of corresponding target in high and low expression cell lines.
This antibody has been used for staining of 44 normal human tissue samples as well as human cancer samples covering the 20 most common cancer types and up to 12 patients for each cancer type. The results are part of an ongoing effort to map the human proteome using antibodies.
Preferentially expressed antigen in melanoma as a novel diagnostic marker differentiating thymic squamous cell carcinoma from thymoma
Sci Rep , 2020 Jul 23; 10:12286. Epub 2020 Jul 23
A therapeutic T cell receptor mimic antibody targets tumor-associated PRAME peptide/HLA-I antigens
J Clin Invest , 2017 Jun 19; 127(7):2705-2718. Epub 2017 Jun 19
Impact of Preferentially Expressed Antigen of Melanoma on the Prognosis of Hepatocellular Carcinoma
Gastrointest Tumors , 2016 Aug 3; 3(3-4):128-135. Epub 2016 Aug 3
The cancer/testis-antigen PRAME supports the pluripotency network and represses somatic and germ cell differentiation programs in seminomas
British Journal of Cancer , July 21, 2016
PRAME expression and promoter hypomethylation in epithelial ovarian cancer
Oncotarget , 2016 Jun 13; 7(29):45352-45369. Epub 2016 Jun 13
PRAME as an independent biomarker for metastasis in uveal melanoma
Clin Cancer Res , 2016 Mar 1; 22(5):1234-1242
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