Highest antigen sequence identity to the following orthologs:
Rat ENSRNOG00000008129 (76%)
Mouse ENSMUSG00000054580 (74%)
Dilution: 1:1000 - 1:2500
Retrieval method: HIER pH6
Working concentration: 0.04-0.4 µg/ml
Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.
Recombinant expression validation in WB using target protein overexpression.
This antibody has been used for staining of 44 normal human tissue samples as well as human cancer samples covering the 20 most common cancer types and up to 12 patients for each cancer type. The results are part of an ongoing effort to map the human proteome using antibodies.
Ultrasensitive Quantitation of Anti-Phospholipase A2 Receptor Antibody as A Diagnostic and Prognostic Indicator of Idiopathic Membranous Nephropathy
Sci Rep , 2017 Sep 21; 7:12049. Epub 2017 Sep 21
Response to immunosuppressive therapy in PLA2R- associated and non-PLA2R- associated idiopathic membranous nephropathy: a retrospective, multicenter cohort study
BMC Nephrol , 2017 Jul 10; 18:227. Epub 2017 Jul 10
The PLA2R1-JAK2 pathway upregulates ERRα and its mitochondrial program to exert tumor-suppressive action
Oncogene , April 04, 2016
Prevalence of Enhanced Granular Expression of Thrombospondin Type-1 Domain-Containing 7A in the Glomeruli of Japanese Patients with Idiopathic Membranous Nephropathy
PLoS One , 2015; 10(9):e0138841. Epub 2015 Sep 22
Prevalence of anti-phospholipase A2 receptor antibodies in Japanese patients with membranous nephropathy
Clin Exp Nephrol , 2015 Aug; 19(4):653-660. Epub 2014 Nov 21
Membranous Nephropathy Associated With Immunological Disorder-Related Liver Disease: A Retrospective Study of 10 Cases
Medicine (Baltimore) , 2015 Jul; 94(30):e1243. Epub 2015 Jul 31
PLA2R1 kills cancer cells by inducing mitochondrial stress.
Free Radic Biol Med , 2013 Dec; 65:969-77. Epub 2013 Aug 29
Kidney biopsy is a sensitive tool for retrospective diagnosis of PLA2R-related membranous nephropathy.
Nephrol Dial Transplant , 2013 Jul; 28(7):1839-44. Epub 2012 Dec 6
Enhanced expression of the M-type phospholipase A2 receptor in glomeruli correlates with serum receptor antibodies in primary membranous nephropathy.
Kidney Int , 2012 Oct; 82(7):797-804. Epub 2012 Jun 6
Autoantibodies specific for the phospholipase A2 receptor in recurrent and De Novo membranous nephropathy.
Am J Transplant , 2011 Oct; 11(10):2144-52. Epub 2011 Aug 9
PLA2R autoantibodies and PLA2R glomerular deposits in membranous nephropathy.
N Engl J Med , 2011 Feb 17; 364(7):689-90
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