Polyclonal Anti-PLA2R1 Antibody
Highest antigen sequence identity to the following orthologs:
Rat ENSRNOG00000008129 (76%)
Mouse ENSMUSG00000054580 (74%)
Dilution: 1:500 - 1:1000
Retrieval method: HIER pH6
Working concentration: 0.04-0.4 µg/ml
Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.
Recombinant expression validation in WB using target protein overexpression.
This antibody has been used for staining of 44 normal human tissue samples as well as human cancer samples covering the 20 most common cancer types and up to 12 patients for each cancer type. The results are part of an ongoing effort to map the human proteome using antibodies.
All characterization data for ENSG00000153246 on the Human Protein Atlas
C5b-9 Glomerular Deposits Are Associated With Poor Renal Survival in Membranous Nephropathy
Kidney Int Rep , 2022 Oct 17; 8(1):103-114. Epub 2022 Oct 17
Anti-phospholipase A2 receptor antibodies directly induced podocyte damage in vitro
Ren Fail , 2022 Mar 25; 44(1):304-313. Epub 2022 Mar 25
Recurrent membranous nephropathy with a possible alteration in the etiology: a case report
BMC Nephrol , 2021 Jul 6; 22:253. Epub 2021 Jul 6
Serine Protease HTRA1 as a Novel Target Antigen in Primary Membranous Nephropathy
J Am Soc Nephrol , 2021 Jul; 32(7):1666-1681. Epub 2021 Jul
Transforming Growth Factor Beta Receptor 3 (TGFBR3)–Associated Membranous Nephropathy
Kidney360 , 2021 Jun 11; 2(8):1275-1286. Epub 2021 Jun 11
Neural cell adhesion molecule 1 is a novel autoantigen in membranous lupus nephritis.
Kidney Int , 2020 Oct 9; 100(1):171-181. Epub 2020 Oct 9
Membranous nephropathy in patients with HIV: a report of 11 cases
BMC Nephrol , 2020 Sep 18; 21:401. Epub 2020 Sep 18
NELL1 is a target antigen in malignancy-associated membranous nephropathy.
Kidney Int , 2020 Aug 20; 99(4):967-976. Epub 2020 Aug 20
Renal Manifestations of Common Variable Immunodeficiency
Kidney360 , 2020 Apr 21; 1(6):491-500. Epub 2020 Apr 21
Ultrasensitive Quantitation of Anti-Phospholipase A2 Receptor Antibody as A Diagnostic and Prognostic Indicator of Idiopathic Membranous Nephropathy
Sci Rep , 2017 Sep 21; 7:12049. Epub 2017 Sep 21
Response to immunosuppressive therapy in PLA2R- associated and non-PLA2R- associated idiopathic membranous nephropathy: a retrospective, multicenter cohort study
BMC Nephrol , 2017 Jul 10; 18:227. Epub 2017 Jul 10
The PLA2R1-JAK2 pathway upregulates ERRα and its mitochondrial program to exert tumor-suppressive action
Oncogene , April 04, 2016
Prevalence of anti-phospholipase A2 receptor antibodies in Japanese patients with membranous nephropathy
Clin Exp Nephrol , 2015 Aug; 19(4):653-660. Epub 2014 Nov 21
Membranous Nephropathy Associated With Immunological Disorder-Related Liver Disease: A Retrospective Study of 10 Cases
Medicine (Baltimore) , 2015 Jul; 94(30):e1243. Epub 2015 Jul 31
Prevalence of Enhanced Granular Expression of Thrombospondin Type-1 Domain-Containing 7A in the Glomeruli of Japanese Patients with Idiopathic Membranous Nephropathy
PLoS One , 2015; 10(9):e0138841. Epub 2015 Sep 22
PLA2R1 kills cancer cells by inducing mitochondrial stress.
Free Radic Biol Med , 2013 Dec; 65:969-77. Epub 2013 Aug 29
PubMed ID: 23994771 DOI: 10.1016/j.freeradbiomed.2013.08.177
Kidney biopsy is a sensitive tool for retrospective diagnosis of PLA2R-related membranous nephropathy.
Nephrol Dial Transplant , 2013 Jul; 28(7):1839-44. Epub 2012 Dec 6
Enhanced expression of the M-type phospholipase A2 receptor in glomeruli correlates with serum receptor antibodies in primary membranous nephropathy.
Kidney Int , 2012 Oct; 82(7):797-804. Epub 2012 Jun 6
Autoantibodies specific for the phospholipase A2 receptor in recurrent and De Novo membranous nephropathy.
Am J Transplant , 2011 Oct; 11(10):2144-52. Epub 2011 Aug 9
PLA2R autoantibodies and PLA2R glomerular deposits in membranous nephropathy.
N Engl J Med , 2011 Feb 17; 364(7):689-90
Did we miss your publication?
Have you published using HPA012657? Please let us know and we will be happy to include your reference on this page.
Join the Explorer Program
Are you using our products in an application or species we have not yet tested? Why not participate in the Explorer Program, and we will show your contribution here. If you would like to share your results with us, the Explorer Program offers a 25µl vial free of charge with your next order.
Our customer support and expert scientific support teams are here to help you succeed in your research.