Highest antigen sequence identity to the following orthologs:
Rat ENSRNOG00000010060 (80%)
Mouse ENSMUSG00000031934 (77%)
Dilution: 1:50 - 1:200
Retrieval method: HIER pH6
Working concentration: 0.04-0.4 µg/ml
Fixation/Permeabilization: PFA/Triton X-100
Working concentration: 0.25-2 µg/ml
Genetic validation in WB by siRNA knockdown.
This antibody has been used for staining of 44 normal human tissue samples as well as human cancer samples covering the 20 most common cancer types and up to 12 patients for each cancer type. The results are part of an ongoing effort to map the human proteome using antibodies.
Age- and sex-dependent role of osteocytic pannexin1 on bone and muscle mass and strength
Sci Rep , 2019 Sep 25; 9:13903. Epub 2019 Sep 25
The P2X7 receptor and pannexin-1 are involved in glucose-induced autocrine regulation in β-cells
Sci Rep , 2018 Jun 12; 8:8926. Epub 2018 Jun 12
Pannexin-1 in Human Lymphatic Endothelial Cells Regulates Lymphangiogenesis
Int J Mol Sci , 2018 May 24; 19(6):1558. Epub 2018 May 24
Manipulation of Panx1 Activity Increases the Engraftment of Transplanted Lacrimal Gland Epithelial Progenitor Cells
Invest Ophthalmol Vis Sci , 2017 Nov; 58(13):5654-5665
Pannexin 1 Modulates Axonal Growth in Mouse Peripheral Nerves
Front Cell Neurosci , 2017 Nov 22; 11:365. Epub 2017 Nov 22
Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity
Arch Toxicol , 2016 Nov 8; 91(5):2245-2261. Epub 2016 Nov 8
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