Highest antigen sequence identity to the following orthologs:
Mouse ENSMUSG00000022574 (86%)
Rat ENSRNOG00000007939 (82%)
Dilution: 1:200 - 1:500
Retrieval method: HIER pH6
Working concentration: 0.04-0.4 µg/ml
Fixation/Permeabilization: PFA/Triton X-100
Working concentration: 0.25-2 µg/ml
Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.
Validation of protein expression in IHC by comparing independent antibodies targeting different epitopes of the protein.
Validated against independent antibody Anti-NAPRT HPA024017.
Validation of protein expression in WB by comparing independent antibodies targeting different epitopes of the protein.
This antibody has been used for staining of 44 normal human tissue samples as well as human cancer samples covering the 20 most common cancer types and up to 12 patients for each cancer type. The results are part of an ongoing effort to map the human proteome using antibodies.
Novel NAPRT specific antibody identifies small cell lung cancer and neuronal cancers as promising clinical indications for a NAMPT inhibitor/niacin co-administration strategy
Oncotarget , 2017 Sep 12; 8(44):77846-77859. Epub 2017 Sep 12
Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors
Oncotarget , 2016 Jan 12; 7(2):1973-1983. Epub 2015 Dec 9
Mapping the subcellular protein distribution in three human cell lines.
J Proteome Res , 2011 Aug 5; 10(8):3766-77. Epub 2011 Jun 29
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