Highest antigen sequence identity to the following orthologs:
Mouse ENSMUSG00000048612 (86%)
Rat ENSRNOG00000016117 (82%)
Dilution: 1:200 - 1:500
Retrieval method: HIER pH6
Working concentration: 0.04-0.4 µg/ml
Fixation/Permeabilization: PFA/Triton X-100
Working concentration: 0.25-2 µg/ml
Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.
Orthogonal validation of protein expression using WB by comparison to RNA-seq data of corresponding target in high and low expression cell lines.
This antibody has been used for staining of 44 normal human tissue samples as well as human cancer samples covering the 20 most common cancer types and up to 12 patients for each cancer type. The results are part of an ongoing effort to map the human proteome using antibodies.
Myoferlin Contributes to the Metastatic Phenotype of Pancreatic Cancer Cells by Enhancing Their Migratory Capacity through the Control of Oxidative Phosphorylation
Cancers (Basel) , 2019 Jun 19; 11(6):853. Epub 2019 Jun 19
Myoferlin controls mitochondrial structure and activity in pancreatic ductal adenocarcinoma, and affects tumor aggressiveness
Oncogene , 2018 May 3; 37(32):4398-4412. Epub 2018 May 3
Myoferlin regulates epithelial cancer cell plasticity and migration through autocrine TGF-β1 signaling
Oncotarget , 2018 Apr 10; 9(27):19209-19222. Epub 2018 Apr 10
A muscle specific protein “myoferlin” modulates IL-6/STAT3 signaling by chaperoning activated STAT3 to nucleus
Oncogene , 2017 Jul 24; 36(46):6374-6382. Epub 2017 Jul 24
Myoferlin is a novel exosomal protein and functional regulator of cancer-derived exosomes
Oncotarget , 2016 Nov 10; 7(50):83669-83683. Epub 2016 Nov 10
Myoferlin regulates cellular lipid metabolism and promotes metastases in triple-negative breast cancer
Oncogene , October 24, 2016
Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development
Sci Rep , 2016 Feb 17; 6:20727. Epub 2016 Feb 17
Loss of Myoferlin Redirects Breast Cancer Cell Motility towards Collective Migration
PLoS One , 2014; 9(2):e86110. Epub 2014 Feb 26
Isolation and characterization of progenitor-like cells from human renal proximal tubules.
Am J Pathol , 2011 Feb; 178(2):828-37
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