Highest antigen sequence identity to the following orthologs:
Mouse ENSMUSG00000017774 (96%)
Rat ENSRNOG00000004072 (96%)
Dilution: 1:50 - 1:200
Retrieval method: HIER pH6
Working concentration: 0.04-0.4 µg/ml
Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.
Validated in Western blot using relevant lysates (see Western blot application images above)
This antibody has been used for staining of 44 normal human tissue samples as well as human cancer samples covering the 20 most common cancer types and up to 12 patients for each cancer type. The results are part of an ongoing effort to map the human proteome using antibodies.
Myosin‐1C uses a novel phosphoinositide‐dependent pathway for nuclear localization
EMBO Rep , 2018 Jan 12; 19(2):290-304. Epub 2018 Jan 12
UNC-45a promotes myosin folding and stress fiber assembly
J Cell Biol , 2017 Dec 4; 216(12):4053-4072
Lowered Expression of Tumor Suppressor Candidate MYO1C Stimulates Cell Proliferation, Suppresses Cell Adhesion and Activates AKT
PLoS One , 2016 Oct 7; 11(10):e0164063. Epub 2016 Oct 7
Analysis of an independent tumor suppressor locus telomeric to Tp53 suggested Inpp5k and Myo1c as novel tumor suppressor gene candidates in this region
BMC Genet , 2015 Jul 14; 16:80. Epub 2015 Jul 14
Loss of functional MYO1C/myosin 1c, a motor protein involved in lipid raft trafficking, disrupts autophagosome-lysosome fusion
Autophagy , 2014 Dec 31; 10(12):2310-2323. Epub 2015 Jan 28
The myosin motor Myo1c is required for VEGFR2 delivery to the cell surface and for angiogenic signaling
Am J Physiol Heart Circ Physiol , 2013 Mar 1; 304(5):H687-H696. Epub 2012 Dec 21
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