Polyclonal Anti-LRG1 Antibody
Highest antigen sequence identity to the following orthologs:
Mouse ENSMUSG00000037095 (63%)
Rat ENSRNOG00000049918 (61%)
Dilution: 1:200 - 1:500
Retrieval method: HIER pH6
Working concentration: 0.04-0.4 µg/ml
Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.
Validated in Western blot using relevant lysates (see Western blot application images above)
This antibody has been used for staining of 44 normal human tissue samples as well as human cancer samples covering the 20 most common cancer types and up to 12 patients for each cancer type. The results are part of an ongoing effort to map the human proteome using antibodies.
All characterization data for ENSG00000171236 on the Human Protein Atlas
LRG1 is an adipokine that promotes insulin sensitivity and suppresses inflammation
eLife , 2022 Nov 8; 11:e81559. Epub 2022 Nov 8
Latrophilin-2 is a novel receptor of LRG1 that rescues vascular and neurological abnormalities and restores diabetic erectile function
Exp Mol Med , 2022 May 13; 54(5):626-638. Epub 2022 May 13
Novel Blood Vascular Endothelial Subtype-Specific Markers in Human Skin Unearthed by Single-Cell Transcriptomic Profiling
Cells , 2022 Mar 25; 11(7):1111. Epub 2022 Mar 25
LRG1 Expression Is Elevated in the Eyes of Patients with Neovascular Age-Related Macular Degeneration
Int J Mol Sci , 2021 Aug 18; 22(16):8879. Epub 2021 Aug 18
Evaluation of leucine-rich alpha-2 glycoprotein as a biomarker of fetal infection
PLoS One , 2020 Nov 19; 15(11):e0242076. Epub 2020 Nov 19
Leucine-rich alpha 2 glycoprotein is a new marker for active disease of tuberculosis
Sci Rep , 2020 Feb 25; 10:3384. Epub 2020 Feb 25
A High-throughput Bead-based Affinity Assay Enables Analysis of Genital Protein Signatures in Women At Risk of HIV Infection
Mol Cell Proteomics , 2019 Mar; 18(3):461-476
Leucine-rich alpha-2-glycoprotein-1 is up-regulated in colorectal cancer and is a tumor promoter
Onco Targets Ther , 2018 May 11; 11:2745-2752. Epub 2018 May 11
Overexpression of leucine‐rich α2‐glycoprotein‐1 is a prognostic marker and enhances tumor migration in gastric cancer
Cancer Sci , 2017 Oct 2; 108(10):2052-2060. Epub 2017 Oct 2
LRG1 promotes proliferation and inhibits apoptosis in colorectal cancer cells via RUNX1 activation
PLoS One , 2017 Apr 4; 12(4):e0175122. Epub 2017 Apr 4
Sputum Leucine-Rich Alpha-2 Glycoprotein as a Marker of Airway Inflammation in Asthma
PLoS One , 2016 Sep 9; 11(9):e0162672. Epub 2016 Sep 9
Tumour expression of bladder cancer-associated urinary proteins.
BJU Int , 2013 Aug; 112(3):407-15. Epub 2013 Mar 7
LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling
Nature , 499, 306-311 (2013)
LRG1 promotes angiogenesis by modulating endothelial TGFß signalling
Nature , 2013 Jul 18; 499(7458):10.1038/nature12345
Did we miss your publication?
Have you published using HPA001888? Please let us know and we will be happy to include your reference on this page.
Join the Explorer Program
Are you using our products in an application or species we have not yet tested? Why not participate in the Explorer Program, and we will show your contribution here. If you would like to share your results with us, the Explorer Program offers a 25µl vial free of charge with your next order.
Our customer support and expert scientific support teams are here to help you succeed in your research.