Dilution: 1:500 - 1:1000
Retrieval method: HIER pH6
Working concentration: 0.4 µg/ml
Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.
Validation of protein expression in IHC by comparing independent antibodies targeting different epitopes of the protein.
Validated against independent antibody Anti-LAMC1 HPA001909.
Validated in Western blot using relevant lysates (see Western blot application images above)
This antibody has been used for staining of 44 normal human tissue samples as well as human cancer samples covering the 20 most common cancer types and up to 12 patients for each cancer type. The results are part of an ongoing effort to map the human proteome using antibodies.
Starved epithelial cells uptake extracellular matrix for survival
Nat Commun , 2017 Jan 10; 8:13989. Epub 2017 Jan 10
Exosomes bind to autotaxin and act as a physiological delivery mechanism to stimulate LPA receptor signalling in cells
J Cell Sci , 2016 Oct 15; 129(20):3948-3957
Laminin C1 expression by uterine carcinoma cells is associated with tumor progression
Gynecol Oncol , 2015/11/01; 139(2):338-344. Epub 2015 Sep 3
Mevalonate Pathway Antagonist Inhibits Proliferation of Serous Tubal Intraepithelial Carcinoma and Ovarian Carcinoma in Mouse Models
Clin Cancer Res , 2015 Jun 24; 21(20):4652-4662. Epub 2015 Jun 24
Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy.
J Proteomics , 2012 Apr 3; 75(7):2236-51. Epub 2012 Feb 15
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