Dilution: 1:200 - 1:500
Retrieval method: HIER pH6
Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.
This antibody has been used for staining of 44 normal human tissue samples as well as human cancer samples covering the 20 most common cancer types and up to 12 patients for each cancer type. The results are part of an ongoing effort to map the human proteome using antibodies.
Overexpression of KDM5B/JARID1B is associated with poor prognosis in hepatocellular carcinoma
Oncotarget , 2018 Sep 28; 9(76):34320-34335. Epub 2018 Sep 28
KDM5 histone demethylases repress immune response via suppression of STING
PLoS Biol , 2018 Aug 6; 16(8):e2006134. Epub 2018 Aug 6
Epigenetic silencing of triple negative breast cancer hallmarks by Withaferin A
Oncotarget , 2017 Apr 13; 8(25):40434-40453. Epub 2017 Apr 13
An easy and efficient inducible CRISPR/Cas9 platform with improved specificity for multiple gene targeting
Nucleic Acids Res , 2016 Jul 25; 44(19):e149. Epub 2016 Jul 25
Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance
Oncotarget , 2016 May 21; 7(26):39931-39944. Epub 2016 May 21
Overexpression of JARID1B is associated with poor prognosis and chemotherapy resistance in epithelial ovarian cancer
Tumour Biol , 2015 Apr; 36(4):2465-2472. Epub 2015 Feb 8
Physical and Functional Interactions between the Histone H3K4 Demethylase KDM5A and the Nucleosome Remodeling and Deacetylase (NuRD) Complex
J Biol Chem , 2014 Oct 17; 289(42):28956-28970. Epub 2014 Sep 4
Histone Demethylase Jumonji AT-rich Interactive Domain 1B (JARID1B) Controls Mammary Gland Development by Regulating Key Developmental and Lineage Specification Genes
J Biol Chem , 2014 Jun 20; 289(25):17620-17633. Epub 2014 May 6
JARID1B is a luminal lineage-driving oncogene in breast cancer
Cancer Cell , 2014 Jun 16; 25(6):762-777
The histone-H3K4-specific demethylase KDM5B binds to its substrate and product through distinct PHD fingers.
Cell Rep , 2014 Jan 30; 6(2):325-35. Epub 2014 Jan 9
The Human Melanoma Side Population Displays Molecular and Functional Characteristics of Enriched Chemoresistance and Tumorigenesis
PLoS One , 2013; 8(10):e76550. Epub 2013 Oct 3
Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway
Mol Cancer , 2010 Mar 13; 9:59. Epub 2010 Mar 13
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