Highest antigen sequence identity to the following orthologs:
Mouse ENSMUSG00000000555 (85%)
Rat ENSRNOG00000057451 (82%)
Dilution: 1:1000 - 1:2500
Retrieval method: HIER pH6
Working concentration: 0.04-0.4 µg/ml
Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.
Orthogonal validation of protein expression using WB by comparison to RNA-seq data of corresponding target in high and low expression cell lines.
This antibody has been used for staining of 44 normal human tissue samples as well as human cancer samples covering the 20 most common cancer types and up to 12 patients for each cancer type. The results are part of an ongoing effort to map the human proteome using antibodies.
Integrin α5 subunit is required for the tumor supportive role of fibroblasts in colorectal adenocarcinoma and serves as a potential stroma prognostic marker
Mol Oncol , 2019 Nov 6; 13(12):2697-2714. Epub 2019 Nov 6
ITGA5 inhibition in pancreatic stellate cells attenuates desmoplasia and potentiates efficacy of chemotherapy in pancreatic cancer
Sci Adv , 2019 Sep 4; 5(9):eaax2770. Epub 2019 Sep 4
Single-cell transcriptomic analysis of primary and metastatic tumor ecosystems in head and neck cancer
Cell , 2017 Nov 30; 171(7):1611-1624.e24. Epub 2017 Nov 30
Survivin promotion of melanoma metastasis requires upregulation of α5 integrin
Carcinogenesis , 2013 Sep; 34(9):2137-2144. Epub 2013 May 2
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