Polyclonal Anti-HOPX Antibody
Highest antigen sequence identity to the following orthologs:
Mouse ENSMUSG00000059325 (74%)
Rat ENSRNOG00000024689 (74%)
Dilution: 1:2500 - 1:5000
Retrieval method: HIER pH6
Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.
This antibody has been used for staining of 44 normal human tissue samples as well as human cancer samples covering the 20 most common cancer types and up to 12 patients for each cancer type. The results are part of an ongoing effort to map the human proteome using antibodies.
All characterization data for ENSG00000171476 on the Human Protein Atlas
Early postnatal defects in neurogenesis in the 3xTg mouse model of Alzheimer’s disease
Cell Death Dis , 2023 Feb 18; 14(2):138. Epub 2023 Feb 18
FGFR2b signalling restricts lineage-flexible alveolar progenitors during mouse lung development and converges in mature alveolar type 2 cells
Cell Mol Life Sci , 2022 Nov 29; 79(12):609. Epub 2022 Nov 29
Human-specific ARHGAP11B ensures human-like basal progenitor levels in hominid cerebral organoids
EMBO Rep , 2022 Sep 13; 23(11):e54728. Epub 2022 Sep 13
Enhanced cortical neural stem cell identity through short SMAD and WNT inhibition in human cerebral organoids facilitates emergence of outer radial glial cells
Nat Cell Biol , 2022 Jun 13; 24(6):981-995. Epub 2022 Jun 13
BRN2 as a key gene drives the early primate telencephalon development
Sci Adv , 2022 Mar 4; 8(9):eabl7263. Epub 2022 Mar 4
Evolutionarily conservative and non-conservative regulatory networks during primate interneuron development revealed by single-cell RNA and ATAC sequencing
Cell Res , 2022 Mar 10; 32(5):425-436. Epub 2022 Mar 10
Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity
Nat Commun , 2021 Nov 2; 12:6298. Epub 2021 Nov 2
H3 acetylation selectively promotes basal progenitor proliferation and neocortex expansion
Sci Adv , 2021 Sep 15; 7(38):eabc6792. Epub 2021 Sep 15
Brain-trait-associated variants impact cell-type-specific gene regulation during neurogenesis
Am J Hum Genet , 2021 Aug 19; 108(9):1647-1668. Epub 2021 Aug 19
Cell-type specific effects of genetic variation on chromatin accessibility during human neuronal differentiation
Nat Neurosci , 2021 May 20; 24(7):941-953. Epub 2021 May 20
TBC1D3 promotes neural progenitor proliferation by suppressing the histone methyltransferase G9a
Sci Adv , 2021 Jan 15; 7(3):eaba8053. Epub 2021 Jan 15
A discrete subtype of neural progenitor crucial for cortical folding in the gyrencephalic mammalian brain
eLife , 2020 Apr 21; 9:e54873. Epub 2020 Apr 21
Centrosome anchoring regulates progenitor properties and cortical formation
Nature , 2020 Mar 25; 580(7801):106-112. Epub 2020 Mar 25
Tight junction protein occludin regulates progenitor Self-Renewal and survival in developing cortex
eLife , 2019 Dec 3; 8:e49376. Epub 2019 Dec 3
Individual brain organoids reproducibly form cell diversity of the human cerebral cortex
Nature , 2019 Jun 5; 570(7762):523-527. Epub 2019 Jun 5
The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice
eLife , 2016 Aug 9; 5:e18197. Epub 2016 Aug 9
Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells.
Nat Methods , 2013 Apr; 10(4):315-23. Epub 2013 Feb 24
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