Dilution: 1:50 - 1:200
Retrieval method: HIER pH6
Working concentration: 0.4 µg/ml
Fixation/Permeabilization: PFA/Triton X-100
Working concentration: 1-4 µg/ml
Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.
Genetic validation in WB by siRNA knockdown.
This antibody has been used for staining of 44 normal human tissue samples as well as human cancer samples covering the 20 most common cancer types and up to 12 patients for each cancer type. The results are part of an ongoing effort to map the human proteome using antibodies.
Combined Secretomics and Transcriptomics Revealed Cancer-Derived GDF15 is Involved in Diffuse-Type Gastric Cancer Progression and Fibroblast Activation
Sci Rep , 2016 Feb 19; 6:21681. Epub 2016 Feb 19
The role of growth differentiation factor 15 in the pathogenesis of primary myelofibrosis
Cancer Med , 2015 Oct; 4(10):1558-1572. Epub 2015 Aug 15
Association of Serum Level of Growth Differentiation Factor 15 with Liver Cirrhosis and Hepatocellular Carcinoma
PLoS One , 2015; 10(5):e0127518. Epub 2015 May 21
Reconstitution of TGFBR2-Mediated Signaling Causes Upregulation of GDF-15 in HCT116 Colorectal Cancer Cells
PLoS One , 2015; 10(6):e0131506. Epub 2015 Jun 26
GDF15 derived from both tumor-associated macrophages and esophageal squamous cell carcinomas contributes to tumor progression via Akt and Erk pathways
Laboratory Investigation , March 02, 2015
GDF-15 is abundantly expressed in plexiform lesions in patients with pulmonary arterial hypertension and affects proliferation and apoptosis of pulmonary endothelial cells
Respir Res , 2011 May 6; 12(1):62. Epub 2011 May 6
Growth differentiation factor 15: a prognostic marker for recurrence in colorectal cancer
Br J Cancer , 2011 May 10; 104(10):1619-1627. Epub 2011 Apr 5
GDF-15 contributes to proliferation and immune escape of malignant gliomas.
Clin Cancer Res , 2010 Aug 1; 16(15):3851-9. Epub 2010 Jun 9
Primary ovarian mucinous carcinoma of intestinal type: significance of pattern of invasion and immunohistochemical expression profile in a series of 31 cases.
Int J Gynecol Pathol , 2010 Mar; 29(2):99-107
Join the Explorer Program
Are you using our products in an application or species we have not yet tested? Why not articipate in the Explorer Program, and we will show your contribution here. If you would like to share your results with us, the Explorer Program offers a 50% of the product price as a refund, or 50% discount on your next vial purchase.