Highest antigen sequence identity to the following orthologs:
Mouse ENSMUSG00000069805 (90%)
Rat ENSRNOG00000017597 (88%)
Dilution: 1:1000 - 1:2500
Retrieval method: HIER pH6
Working concentration: 0.04-0.4 µg/ml
Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.
Validated in Western blot using relevant lysates (see Western blot application images above)
This antibody has been used for staining of 44 normal human tissue samples as well as human cancer samples covering the 20 most common cancer types and up to 12 patients for each cancer type. The results are part of an ongoing effort to map the human proteome using antibodies.
The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation
eLife , 2018 Jun 18; 7:e35528. Epub 2018 Jun 18
Antagonism of PPARγ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis
Nat Med , 2018 Jan 29; 24(3):360-367. Epub 2018 Jan 29
Targeted knockdown of polo-like kinase 1 alters metabolic regulation in melanoma
Cancer Lett , 2017 Feb 22; 394:13-21. Epub 2017 Feb 22
Alternate metabolic programs define regional variation of relevant biological features in renal cell carcinoma progression
Clin Cancer Res , 2016 Jan 19; 22(12):2950-2959. Epub 2016 Jan 19
Fructose-1, 6-bisphosphatase opposes renal carcinoma progression
Nature , 2014 Sep 11; 513(7517):251-255. Epub 2014 Jul 20
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