Highest antigen sequence identity to the following orthologs:
Mouse ENSMUSG00000005087 (51%)
Rat ENSRNOG00000006094 (47%)
Dilution: 1:1000 - 1:2500
Retrieval method: HIER pH6
Working concentration: 0.04-0.4 µg/ml
Fixation/Permeabilization: PFA/Triton X-100
Working concentration: 0.25-2 µg/ml
Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.
Orthogonal validation of protein expression using WB by comparison to RNA-seq data of corresponding target in high and low expression cell lines.
This antibody has been used for staining of 44 normal human tissue samples as well as human cancer samples covering the 20 most common cancer types and up to 12 patients for each cancer type. The results are part of an ongoing effort to map the human proteome using antibodies.
CUL4B contributes to cancer stemness by repressing tumor suppressor miR34a in colorectal cancer
Oncogenesis , 2020 Feb 13; 9(2):20. Epub 2020 Feb 13
Cancer Stem-Cell Marker CD44v9-Positive Cells Arise From Helicobacter pylori–Infected CAPZA1-Overexpressing Cells
Cell Mol Gastroenterol Hepatol , 2019 May 27; 8(3):319-334. Epub 2019 May 27
Experimental Model of Human Malignant Mesothelioma in Athymic Mice
Int J Mol Sci , 2018 Jun 26; 19(7):1881. Epub 2018 Jun 26
Distinctive epigenomes characterize glioma stem cells and their response to differentiation cues
Genome Biol , 2018 Mar 27; 19:43. Epub 2018 Mar 27
Toward early detection of Helicobacter pylori-associated gastric cancer
Gastric Cancer , 2017 Jul 19; 21(2):196-203. Epub 2017 Jul 19
Protein and glycomic plasma markers for early detection of adenoma and colon cancer
Gut , 2016 Nov 7; 67(3):473-484. Epub 2016 Nov 7
Loss of KCNQ1 expression in stage II and stage III colon cancer is a strong prognostic factor for disease recurrence
Br J Cancer , 2016 Nov 17; 115(12):1565-1574. Epub 2016 Nov 17
The Role of CD44 and ERM Proteins in Expression and Functionality of P-glycoprotein in Breast Cancer Cells
Molecules , 2016 Mar 1; 21(3):290. Epub 2016 Mar 1
Endocardial-to-mesenchymal transformation and mesenchymal cell colonization at the onset of human cardiac valve development
Development , 2016/02/01; 143(3):473-482
Role of MIF/CD74 signaling pathway in the development of pleural mesothelioma
Oncotarget , 2016 Feb 11; 7(10):11512-11525. Epub 2016 Feb 11
Murine model: maternal administration of stem cells for prevention of prematurity
Am J Obstet Gynecol , 2014 Dec 30; 212(5):639.e1-639.10. Epub 2014 Dec 30
Superficial scrapings from breast tumors is a source for biobanking and research purposes
Laboratory Investigation , 94, 796-805 (2014)
Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay.
Nat Biotechnol , 2013 Jun; 31(6):539-44. Epub 2013 Apr 21
Optimization of tumor xenograft dissociation for the profiling of cell surface markers and nutrient transporters.
Lab Invest , 2013 May; 93(5):611-21. Epub 2013 Mar 4
Metformin regulates breast cancer stem cell ontogeny by transcriptional regulation of the epithelial-mesenchymal transition (EMT) status.
Cell Cycle , 2010 Sep 15; 9(18):3807-14. Epub 2010 Sep 25
Synthesis of hyaluronan in oesophageal cancer cells is uncoupled from the prostaglandin–cAMP pathway
Br J Pharmacol , 2009 May; 157(2):234-243. Epub 2009 Mar 26
Expression profiling of microdissected cell populations selected from basal cells in normal epidermis and basal cell carcinoma.
Br J Dermatol , 2008 Mar; 158(3):527-38. Epub 2008 Jan 30
EpCAM-Independent Enrichment of Circulating Tumor Cells in Metastatic Breast Cancer
PLoS One , 1/01/01; 10(12):e0144535. Epub 2015 Dec 22
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