Polyclonal Anti-ATF3 Antibody


Highest antigen sequence identity to the following orthologs:
Rat ENSRNOG00000003745 (92%)
Mouse ENSMUSG00000026628 (92%)
Recommended conditions:
Dilution: 1:200 - 1:500
Retrieval method: HIER pH6
Recommended conditions:
Fixation/Permeabilization: PFA/Triton X-100
Working concentration: 0.25-2 µg/ml
This antibody has been used for staining of 44 normal human tissue samples as well as human cancer samples covering the 20 most common cancer types and up to 12 patients for each cancer type. The results are part of an ongoing effort to map the human proteome using antibodies.
All characterization data for ENSG00000162772 on the Human Protein Atlas
Genome-Wide Expression Profiling by RNA-Sequencing in Spinal Cord Dorsal Horn of a Rat Chronic Postsurgical Pain Model to Explore Potential Mechanisms Involved in Chronic Pain
J Pain Res , 2022 Apr 5; 15:985-1001. Epub 2022 Apr 5
Decreased expression of ATF3, orchestrated by β-catenin/TCF3, miR-17-5p and HOXA11-AS, promoted gastric cancer progression via increased β-catenin and CEMIP
Exp Mol Med , 2021 Nov 2; 53(11):1706-1722. Epub 2021 Nov 2
Exercise-induced angiogenesis is dependent on metabolically primed ATF3/4+ endothelial cells
Cell Metab , 2021 Sep 7; 33(9):1793-1807.e9
Gene Expression Profiling of Contralateral Dorsal Root Ganglia Associated with Mirror-Image Pain in a Rat Model of Complex Regional Pain Syndrome Type-I
J Pain Res , 2021 Sep 4; 14:2739-2756. Epub 2021 Sep 4
Increased Expression of Thymic Stromal Lymphopoietin in Chronic Constriction Injury of Rat Nerve
Int J Mol Sci , 2021 Jul 1; 22(13):7105. Epub 2021 Jul 1
ATF3 deficiency impairs the proliferative–secretory phase transition and decidualization in RIF patients
Cell Death Dis , 2021 Apr 12; 12(4):387. Epub 2021 Apr 12
Transcriptome profiling of long noncoding RNAs and mRNAs in spinal cord of a rat model of paclitaxel-induced peripheral neuropathy identifies potential mechanisms mediating neuroinflammation and pain
J Neuroinflammation , 2021 Feb 18; 18:48. Epub 2021 Feb 18
Atrophy and Death of Nonpeptidergic and Peptidergic Nociceptive Neurons in SIV Infection
Am J Pathol , 2020 Jul; 190(7):1530-1544
The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development
Nat Neurosci , 2020 Jul 13; 23(9):1067-1078. Epub 2020 Jul 13
Activating transcription factor 3 coordinates differentiation of cardiac and hematopoietic progenitors by regulating glucose metabolism
Sci Adv , 2020 May 6; 6(19):eaay9466. Epub 2020 May 6
Interference with SRF expression in skeletal muscles reduces peripheral nerve regeneration in mice
Sci Rep , 2020 Mar 24; 10:5281. Epub 2020 Mar 24
Single-Cell RNA Transcriptome Helps Define the Limbal/Corneal Epithelial Stem/Early Transit Amplifying Cells and How Autophagy Affects This Population
Invest Ophthalmol Vis Sci , 2019 Aug; 60(10):3570-3583
Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling
Nat Neurosci , 2019 Jun 17; 22(7):1075-1088. Epub 2019 Jun 17
The stress response gene ATF3 is a direct target of the Wnt/β-catenin pathway and inhibits the invasion and migration of HCT116 human colorectal cancer cells
PLoS One , 2018 Jul 2; 13(7):e0194160. Epub 2018 Jul 2
Inhibiting the integrated stress response pathway prevents aberrant chondrocyte differentiation thereby alleviating chondrodysplasia
eLife , 2018 Jul 19; 7:e37673. Epub 2018 Jul 19
Defining the Transcriptional Targets of Leptin Reveals a Role for Atf3 in Leptin Action
Diabetes , 2018 Mar 13; 67(6):1093-1104. Epub 2018 Mar 13
ATF3 represses PINK1 gene transcription in lung epithelial cells to control mitochondrial homeostasis
Aging Cell , 2018 Jan 24; 17(2):e12720. Epub 2018 Jan 24
Activating transcription factor 3 promotes embryo attachment via up-regulation of leukemia inhibitory factor in vitro
Reprod Biol Endocrinol , 2017 Jun 2; 15:42. Epub 2017 Jun 2
Palmitate Increases β-site AβPP-Cleavage Enzyme 1 Activity and Amyloid-β Genesis by Evoking Endoplasmic Reticulum Stress and Subsequent C/EBP Homologous Protein Activation
J Alzheimers Dis , 2017 Apr 10; 57(3):907-925. Epub 2017 Apr 10
Atf3 mutant mice show reduced axon regeneration and impaired regeneration-associated gene induction after peripheral nerve injury
Open Biol , 2016 Aug 31; 6(8):160091. Epub 2016 Aug 31
Role of Activating Transcription Factor 3 (ATF3) in Endoplasmic Reticulum (ER) Stress-induced Sensitization of p53-deficient Human Colon Cancer Cells to Tumor Necrosis Factor (TNF)-related Apoptosis-inducing Ligand (TRAIL)-mediated Apoptosis through Up-regulation of Death Receptor 5 (DR5) by Zerumbone and Celecoxib
J Biol Chem , 2014 Aug 1; 289(31):21544-21561. Epub 2014 Jun 17
The Activating Transcription Factor 3 Protein Suppresses the Oncogenic Function of Mutant p53 Proteins
J Biol Chem , 2014 Mar 28; 289(13):8947-8959. Epub 2014 Feb 19
Immunohistochemical Detection of Activating Transcription Factor 3, a Hub of the Cellular Adaptive–Response Network
Methods Enzymol , 2011; 490:175-194
Opposing roles for calcineurin and ATF3 in squamous skin cancer.
Nature , 2010 May 20; 465(7296):368-72
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