Polyclonal Anti-AQP4 Antibody



Highest antigen sequence identity to the following orthologs:
Mouse ENSMUSG00000024411 (93%)
Rat ENSRNOG00000016043 (92%)
Recommended conditions:
Dilution: 1:2500 - 1:5000
Retrieval method: HIER pH6
Recommended conditions:
Working concentration: 0.04-0.4 µg/ml
Recommended conditions:
Fixation/Permeabilization: PFA/Triton X-100
Working concentration: 0.25-2 µg/ml
Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.
Validated in Western blot using relevant lysates (see Western blot application images above)
This antibody has been used for staining of 44 normal human tissue samples as well as human cancer samples covering the 20 most common cancer types and up to 12 patients for each cancer type. The results are part of an ongoing effort to map the human proteome using antibodies.
All characterization data for ENSG00000171885 on the Human Protein Atlas
Post-transcriptional control of a stemness signature by RNA-binding protein MEX3A regulates murine adult neurogenesis
Nat Commun , 2023 Jan 23; 14:373. Epub 2023 Jan 23
Altered dynamics of glymphatic flow in a mature-onset Tet-off APP mouse model of amyloidosis
Alzheimers Res Ther , 2023 Jan 28; 15:23. Epub 2023 Jan 28
Sleep fragmentation affects glymphatic system through the different expression of AQP4 in wild type and 5xFAD mouse models
Acta Neuropathol Commun , 2023 Jan 18; 11:16. Epub 2023 Jan 18
Histochemical Comparison of Human and Rat Lacrimal Glands: Implications for Bio-Engineering Studies
Transl Vis Sci Technol , 2022 Nov 14; 11(11):10. Epub 2022 Nov 14
Evidence of beta amyloid independent small vessel disease in familial Alzheimer's disease
Brain Pathol , 2022 Jun 13; 32(6):e13097. Epub 2022 Jun 13
Cell type-specific biotin labeling in vivo resolves regional neuronal and astrocyte proteomic differences in mouse brain
Nat Commun , 2022 May 25; 13:2927. Epub 2022 May 25
An open source toolkit for repurposing Illumina sequencing systems as versatile fluidics and imaging platforms
Sci Rep , 2022 Mar 24; 12:5081. Epub 2022 Mar 24
MS‐Driven Metabolic Alterations Are Recapitulated in iPSC‐Derived Astrocytes
Ann Neurol , 2022 Mar 17; 91(5):652-669. Epub 2022 Mar 17
Multiple therapeutic effects of human neural stem cells derived from induced pluripotent stem cells in a rat model of post-traumatic syringomyelia
EBioMedicine , 2022 Feb 16; 77:103882. Epub 2022 Feb 16
A panel of CSF proteins separates genetic frontotemporal dementia from presymptomatic mutation carriers: a GENFI study
Mol Neurodegener , 2021 Nov 27; 16:79. Epub 2021 Nov 27
Multi‐cohort profiling reveals elevated CSF levels of brain‐enriched proteins in Alzheimer’s disease
Ann Clin Transl Neurol , 2021 Jun 15; 8(7):1456-1470. Epub 2021 Jun 15
Protocol for Cloning Epithelial Stem Cell Variants from Human Lung
STAR Protoc , 2020 Jul 9; 1(2):100063. Epub 2020 Jul 9
CD49f is a novel marker of functional and reactive human iPSC-derived astrocytes
Neuron , 2020 Jun 1; 107(3):436-453.e12. Epub 2020 Jun 1
Isolation of Mouse Cerebral Microvasculature for Molecular and Single-Cell Analysis
Front Cell Neurosci , 2020 Apr 9; 14:84. Epub 2020 Apr 9
Effects of advanced age upon astrocyte-specific responses to acute traumatic brain injury in mice
J Neuroinflammation , 2020 Apr 14; 17:115. Epub 2020 Apr 14
Regenerative Metaplastic Clones in COPD Lung Drive Inflammation and Fibrosis
Cell , 2020 Apr 15; 181(4):848-864.e18. Epub 2020 Apr 15
Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes
Nat Commun , 2019 Jun 27; 10:2817. Epub 2019 Jun 27
Therapeutic Target and Cell-signal Communication of Chlorpromazine and Promethazine in Attenuating Blood–Brain Barrier Disruption after Ischemic Stroke
Cell Transplant , 2018 Dec 20; 28(2):145-156. Epub 2018 Dec 20
Multiple origins and modularity in the spatiotemporal emergence of cerebellar astrocyte heterogeneity
PLoS Biol , 2018 Sep 27; 16(9):e2005513. Epub 2018 Sep 27
A recurrent point mutation in PRKCA is a hallmark of chordoid gliomas
Nat Commun , 2018 Jun 18; 9:2371. Epub 2018 Jun 18
A role for ErbB signaling in the induction of reactive astrogliosis
Cell Discov , 2017 Dec 5; 3:17044-. Epub 2017 Dec 5
Neurotoxic reactive astrocytes are induced by activated microglia
Nature , 2017 Jan 18; 541(7638):481-487. Epub 2017 Jan 18
Changes in Cannabinoid Receptors, Aquaporin 4 and Vimentin Expression after Traumatic Brain Injury in Adolescent Male Mice. Association with Edema and Neurological Deficit
PLoS One , 2015; 10(6):e0128782. Epub 2015 Jun 3
Human neural progenitor cells generated from induced pluripotent stem cells can survive, migrate, and integrate in the rodent spinal cord
J Comp Neurol , 2014 Aug 15; 522(12):2707-2728. Epub 2014 Apr 12
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