Polyclonal Anti-ACO2 Antibody
Highest antigen sequence identity to the following orthologs:
Mouse ENSMUSG00000022477 (97%)
Rat ENSRNOG00000024128 (97%)
Dilution: 1:500 - 1:1000
Retrieval method: HIER pH6
Working concentration: 0.04-0.4 µg/ml
Fixation/Permeabilization: PFA/Triton X-100
Working concentration: 0.25-2 µg/ml
Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.
Validated in Western blot using relevant lysates (see Western blot application images above)
This antibody has been used for staining of 44 normal human tissue samples as well as human cancer samples covering the 20 most common cancer types and up to 12 patients for each cancer type. The results are part of an ongoing effort to map the human proteome using antibodies.
Mitochondrial Aconitase ACO2 Links Iron Homeostasis with Tumorigenicity in Non–Small Cell Lung Cancer
Mol Cancer Res , 2022 Oct 10; 21(1):36-50. Epub 2022 Oct 10
Mice harboring the FXN I151F pathological point mutation present decreased frataxin levels, a Friedreich ataxia-like phenotype, and mitochondrial alterations
Cell Mol Life Sci , 2022 Jan 17; 79(2):74. Epub 2022 Jan 17
Ketogenic diet ameliorates axonal defects and promotes myelination in Pelizaeus–Merzbacher disease
Acta Neuropathol , 2019 Mar 27; 138(1):147-161. Epub 2019 Mar 27
Integrative proteomics in prostate cancer uncovers robustness against genomic and transcriptomic aberrations during disease progression
Nat Commun , 2018 Mar 21; 9:1176. Epub 2018 Mar 21
STED Super-Resolution Microscopy of Clinical Paraffin-Embedded Human Rectal Cancer Tissue
PLoS One , 2014; 9(7):e101563. Epub 2014 Jul 15
Mitochondrial aconitase knockdown attenuates paraquat-induced dopaminergic cell death via decreased cellular metabolism and release of iron and H₂O₂.
J Neurochem , 2011 Jul; 118(1):79-92. Epub 2011 May 19
Join the Explorer Program
Are you using our products in an application or species we have not yet tested? Why not participate in the Explorer Program, and we will show your contribution here. If you would like to share your results with us, the Explorer Program offers a 25µl vial free of charge with your next order.