Monoclonal Anti-WWTR1 Antibody



Human Protein Atlas
Highest antigen sequence identity to the following orthologs:
Mouse ENSMUSG00000027803 (96%)
Rat ENSRNOG00000016617 (96%)
Recommended conditions:
Dilution: 1:50 - 1:200
Retrieval method: HIER pH6
Recommended conditions:
Working concentration: 1 µg/ml
Recommended conditions:
Fixation/Permeabilization: PFA/Triton X-100
Working concentration: 2-10 µg/ml
Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.
Genetic validation in WB by siRNA knockdown.
The Hippo pathway effector TAZ induces intrahepatic cholangiocarcinoma in mice and is ubiquitously activated in the human disease
J Exp Clin Cancer Res , 2022 Jun 3; 41:192. Epub 2022 Jun 3
The Hippo Effector Transcriptional Coactivator with PDZ-Binding Motif Cooperates with Oncogenic β-Catenin to Induce Hepatoblastoma Development in Mice and Humans
Am J Pathol , 2020 Jul; 190(7):1397-1413
Hippo-YAP1 Is a Prognosis Marker and Potentially Targetable Pathway in Advanced Gallbladder Cancer
Cancers (Basel) , 2020 Mar 25; 12(4):778. Epub 2020 Mar 25
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