Antibodies for SOX Proteins

Explore our antibodies targeting the SOX family of proteins. Find a wide selection of antibodies for the different SOX family proteins, covering most of the subgroups with a range of monoclonal and polyclonal antibodies, validated for IHC, ICC-IF and Western blot.

A selection of the antibodies are supplied with images visualizing structures such as neural tube,  developing brain, eye and trigeminal ganglion and developing cartilage.

The SOX protein family

The SOX proteins belong to a family of transcription factors with a conserved high-mobility group (HMG) domain. The 20 SOX proteins currently known are implicated in processes such as the development of the nervous system, reproduction system as well as tumorigenesisBased on the HMG domain homology, SOX proteins are divided into different groups termed A to H, having distinct biological functions.

Staining of mouse embryo E11
Staining of mouse embryo E11 with Anti-SOX9 antibody shows reactivity in the developing eye.

Antibodies targeting the SOXB1 proteins

The SOXB1 proteins are important for the early embryonal CNS development. They are also expressed in adult neural stem cells. SOX2 is one of the essential transcription factors contributing to the embryonic stem cell state and further development of the central nervous system. SOX3 is involved in early neuronal development and male sex development. See available antibodies for SOX2 and SOX3 below. 

Anti-SOX2 monoclonal antibody (AMAb91307)       

  • validated for IHC, WB, ICC-IF
  • sequence identity mouse/rat: 99% / 99%

Anti-SOX2 polyclonal antibody (HPA045725)

  • validated for WB, ICC-IF
  • sequence identity mouse/rat: 99% / 99%

Anti-SOX3 monoclonal antibody (AMAb91312)       

  • validated for WB
  • sequence identity mouse/rat: 82% / 31%

Anti-SOX3 polyclonal antibody (HPA054720)

  • validated for ICC-IF
  • sequence identity mouse/rat: 93% / 41%

Anti-SOX3 polyclonal antibody (HPA075003)

  • validated for ICC-IF
  • sequence identity mouse/rat: 76% / 36%
Tissue expression of various SOX factors belonging to SOXB1-SOXH groups visualized using fluorescence or chromogenic immunohistochemistry
Tissue expression of various SOX factors belonging to SOXB1-SOXH groups visualized using fluorescence or chromogenic immunohistochemistry. SOX2 in mouse embryo E11 neural tube using Anti-SOX2 antibody AMAb91307 (A), SOX21 in mouse brain using Anti-SOX21 antibody AMAb91311 (B), SOX4 in mouse brain rostral migratory stream using Anti-SOX4 antibody AMAb91378 (C), SOX6 in human testis using Anti-SOX6 antibody HPA001923 (D), SOX9 in mouse embryo E14 cartilage using Anti-SOX9 antibody AMAb90795 (E), SOX17 in human endometrium using Anti-SOX17 antibody HPA068399 (F), SOX15 in human esophagus using Anti-SOX15 antibody HPA067196 (G), SOX30 in human testis using Anti-SOX30 antibody HPA006159 (H).

Antibodies targeting the SOXB2 proteins

The SOXB2 group includes SOX21, expressed in immature neurons and contributes to the progression of neuronal development. See available antibodies against SOX21 below.              

Anti-SOX21 monoclonal antibody (AMAb91309)     

  • validated for IHC, WB
  • sequence identity mouse/rat: 100% / n.d.

Anti-SOX21 monoclonal antibody (AMAb91311)     

  • validated for IHC, WB
  • sequence identity mouse/rat: 100% / n.d.

Anti-SOX21 polyclonal antibody (HPA064084)         

  • validated for ICC-IF
  • sequence identity mouse/rat: 96% / 37%

Antibodies targeting the SOXC proteins

Proteins in the SOXC group include SOX4, SOX11 and SOX12, where SOX4 is involved in neural lineage progression, bone development and tumorigenesis. SOX11 has a role in both CNS development and tumorigenesis. For instance, Mantle Cell Lymphoma can be diagnosed by overexpression of the SOX11 protein. SOX12 is involved in the CNS and male and female tissue. See available antibodies against SOX4, SOX11 and SOX12 below. 

Anti-SOX4 polyclonal antibody (HPA029901)

  • validated for IHC, ICC-IF
  • sequence identity mouse/rat: 100% / 39%

Anti-SOX4 monoclonal antibody (AMAb91378)       

  • validated for IHC, ICC-IF
  • sequence identity mouse/rat: 78% / n.d.

Anti-SOX4 monoclonal antibody (AMAb91380)       

  • validated for IHC, ICC-IF
  • sequence identity mouse/rat: 78% / n.d.

Anti-SOX11 monoclonal antibody (AMAb90501)     

  • validated for IHC, WB
  • sequence identity mouse/rat: 82% / 82%

Anti-SOX11 monoclonal antibody (AMAb90502)     

  • validated for IHC, WB
  • sequence identity mouse/rat: 82% / 82%

Anti-SOX11 polyclonal antibody (HPA000536)         

  • validated for IHC, WB
  • sequence identity mouse/rat: 82% / 82%

Anti-SOX12 polyclonal antibody (HPA055052)         

  • validated for ICC-IF
  • sequence identity mouse/rat: 96% / 96%

Anti-SOX12 polyclonal antibody (HPA061627)         

  • validated for ICC-IF
  • sequence identity mouse/rat: 91% / 91%

Antibodies targeting the SOXD proteins

Proteins in the SOXD group include SOX5, SOX5 and SOX13. SOX5 and SOX6 are involved in chondrogenesis and tumorigenesis. SOX6 also contributes in neural system development and maintenance of cardiac and skeletal muscle. Overexpression of SOX6 is seen in malignant glioma. SOX13 is involved in embryonic development and diabetes. See available antibodies targeting SOX5, SOX6 and SOX13 below. 

Anti-SOX5 polyclonal antibody (HPA060499)

  • validated for WB, ICC-IF
  • sequence identity mouse/rat: 91% / 88%

Anti-SOX6 polyclonal antibody (HPA001923)

  • validated for IHC, ICC-IF            
  • sequence identity mouse/rat: 96% / 96%

Anti-SOX6 polyclonal antibody (HPA003908)

  • validated for IHC, WB
  • sequence identity mouse/rat: 97% / 95%

Anti-SOX6 monoclonal antibody (AMAb91382)       

  • validated for WB
  • sequence identity mouse/rat: 84% / n.d.

Anti-SOX6 monoclonal antibody (AMAb91383)       

  • validated for IHC, ICC-IF
  • sequence identity mouse/rat: 84% / n.d.

Anti-SOX13 polyclonal antibody (HPA051790)         

  • validated for ICC-IF
  • sequence identity mouse/rat: 87% / 87%

Anti-SOX13 polyclonal antibody (HPA054853)         

  • validated for ICC-IF
  • sequence identity mouse/rat: 93% / 87%
IHC staining of human high grade glioma with Anti-SOX6 antibody HPA001923
IHC staining of human high-grade glioma with Anti-SOX6 antibody HPA001923 shows strong nuclear immunoreactivity in tumor cells (A). IHC staining of human mantle cell lymphoma with Anti-SOX11 antibody HPA000536 shows nuclear positivity in tumor cells (B), compared to the absence of nuclear positivity in a control chronic lymphocytic leukemia shown in (C).

Antibodies targeting the SOXE proteins

Proteins in the SOXE group are involved in CNS gliogenesis and include SOX8, SOX9, SOX10. 

SOX8 is involved in CNS, limb, and facial development, as well as male sex determination. SOX9 contributes to neural crest development, gliogenesis, chondrocyte differentiation and glioma. SOX10 is essential for terminal oligodendrocyte differentiation in the CNS. In the peripheral nervous system, SOX10 is required for specification of the glial cells.

Anti-SOX8 polyclonal antibody (HPA058665)

  • validated for IHC, ICC-IF
  • sequence identity mouse/rat: 73% / 70%

Anti-SOX9 monoclonal antibody (AMAb90795)       

  • validated for IHC, WB, ICC-IF
  • sequence identity mouse/rat: 97% / 96%

Anti-SOX9 polyclonal antibody (HPA001758)

  • validated for IHC, WB, ICC-IF
  • sequence identity mouse/rat: 97% / 96%

Anti-SOX10 monoclonal antibody (AMAb91297)     

  • validated for IHC, ICC-IF
  • sequence identity mouse/rat: 98% / 98%

Anti-SOX10 polyclonal antibody (HPA068898)         

  • validated for IHC, ICC-IF
  • sequence identity mouse/rat: 98% / 98%
SOX9 expression in the developing dorsal neural tube of mouse embryo E11
SOX9 expression in the developing dorsal neural tube of mouse embryo E11 shown by IHC-IF with Anti-SOX9 AMAb90795 (A). SOX9 expression in adult human testis shown by IHC with Anti-SOX9 antibody HPA001758 (B). SOX6 expression in human testis visualized by Anti-SOX6 antibody HPA001923 (C).

Antibodies targeting the SOXF proteins

Proteins in the SOXF group includes SOX7, SOX17 and SOX18. SOX7 is involved with hematopoietic/endothelial development and suppression of tumorigenesis. The SOX17 protein is involved in gut and heart development and tumorigenesis and SOX18 in hair, blood vessel and lymphatic vessel development.  

Anti-SOX7 polyclonal antibody (HPA009065)

  • validated for IHC, WB
  • sequence identity mouse/rat: 91% / 91%

Anti-SOX17 polyclonal antibody (HPA068399)         

  • validated for IHC
  • sequence identity mouse/rat: 89% / 87%

Anti-SOX18 monoclonal antibody (HPA073703)       

  • validated for ICC-IF
  • sequence identity mouse/rat: 89% / 89%

Antibodies targeting the SOXG proteins

Proteins in the SOXG group include the SOX15 protein, involved in muscle differentiation and tumorigenesis.  

Anti-SOX15 polyclonal antibody (HPA067196)         

  • validated for IHC, ICC-IF
  • sequence identity mouse/rat: 52% / 52%

Anti-SOX15 polyclonal antibody (HPA074049)         

  • validated for ICC-IF
  • sequence identity mouse/rat: 71% / 36%

Antibodies targeting the SOXH proteins

Proteins in the SOXH group include SOX30, involved with differentiation of developing male germ cells. See available antibodies against SOX30 below.

Anti-SOX30 polyclonal antibody (HPA006159)         

  • validated for IHC, WB
  • sequence identity mouse/rat: 68% / 70%