Cell Cycle Markers

The cell cycle is a series of processes, including cell proliferation, that a cell undergoes during its life cycle. Cancer lesions commonly originate from aberrant cellular proliferation.

Abnormal cellular proliferation can be caused by mutations or amplifications in the open-reading frames or regulatory domains of oncogenes and tumor suppressors that regulate cell growth.

Cell cycle regulation

Cell cycle progression is positively regulated and enforced by a family of serine/threonine protein kinases collectively referred to as cyclin-dependent kinases (CDKs). CDKs are activated by binding to respective cyclin partners and by phosphorylation.

These checkpoint pathways recognize and sense whether or not to initiate and/or promote cellular proliferation under a particular set of external and internal conditions. Crucial components of these pathways are mainly proteins encoded by some checkpoint genes including the tumor suppressor protein p53.

IHC staining of human squamous cell carcinoma using Anti-p53 Antibody (AMAb90946) showing strong nuclear positivity in tumor cells.

Mechanisms in Cancer

Download our white paper to learn about the mechanisms in cancer and protein markers used in cancer research.

Download white paper

Antibodies targeting cell cycle markers

Atlas Antibodies offer a range of primary antibodies targeting cell cycle markers. Selected antibodies are listed below.

IHC staining, WB analysis and ICC-IF staining using Anti-p53 antibody (AMAb90956). — Left: IHC staining of human colorectal cancer using the Anti-p53 antibody (AMAb90956) showing strong nuclear positivity in tumor cells but not in normal mucosa. Middle: WB analysis in U-251 cells transfected with control siRNA, target-specific siRNA probes using the same Anti-p53 antibody. Right: ICC-IF staining in A431 cells using the same Anti-p53 antibody, showing cell cycle-dependent nuclear (without nucleoli) staining in green. Microtubules are visualized in red.

Anti-p53 monoclonal antibody (AMAb90956)

Validated for IHC, WB, ICC-IF
Sequence identity mouse/rat 91%/75%

Cell Cycle Markers

Cell cycle regulation

Mechanisms in Cancer

Antibodies targeting cell cycle markers

Anti-p53 monoclonal antibody (AMAb90956)

amab90956 Anti-p53 polyclonal antibody (HPA051244)

Anti-AURKA polyclonal antibody (HPA002636)

Anti-AURKB polyclonal antibody (HPA037708)

Anti-CCNA1/CyclinA1 polyclonal antibody (HPA060646)

Anti-CCNB1/CyclinB1 polyclonal antibody (HPA030741)

Anti-CCNB1/CyclinB1 polyclonal antibody (HPA061448)

Anti-CCNB2/CyclinB2 Polyclonal antibody (HPA008873)validated for IHC, WB, ICC-IF sequence identity mouse/rat 81%/27%

Anti-CCNB3/CyclinB3 polyclonal antibody (HPA000496)

Anti-CCND1/ CyclinD1 polyclonal antibody (HPA027802)

Anti-CCND2/CyclinD2 polyclonal antibody (HPA049138)

Anti-CCND2/CyclinD2 polyclonal antibody (HPA054196)

Anti-CDK2 monoclonal antibody (AMAb91497)

Anti-CDK4 monoclonal antibody (AMAb91499)

Anti-CDK5 polyclonal antibody (HPA064535)

Anti-CDK6 polyclonal antibody (HPA002637)

nti-CDKN2A polyclonal antibody (HPA047838)

Anti-CDKN2B polyclonal antibody (HPA063327)

Anti-CDKN2D polyclonal antibody (HPA043546)

Anti-CHEK1 polyclonal antibody (HPA044364)

Anti-CHEK2 monoclonal antibody (AMAb91570)

Anti-E2F1 polyclonal antibody (HPA029735)

Anti-PLK1 polyclonal antibody (HPA051638)

Anti-PLK1 polyclonal antibody (HPA053229)

Anti-PLK1 monoclonal antibody (AMAb91515)

Anti-RB1 polyclonal antibody (HPA050082)

Anti-RIF1 polyclonal antibody (HPA036887)

Anti-RIF1 polyclonal antibody (HPA036888)

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