Laminins Marker Panel

Laminins play a crucial role in maintaining tissue integrity and regulating cellular behavior in normal development and homeostasis. 

Laminins are a family of large, multidomain glycoproteins that are crucial components of the extracellular matrix (ECM) in animal tissues. They play a fundamental role in providing structural support to cells and tissues. 

A laminin molecule is typically composed of three different chains (α, β, and γ) that assemble to form a cross-shaped structure. This structure gives laminins their characteristic ability to connect with other molecules in the extracellular matrix and interact with cell surface receptors.

Laminins are involved in various cellular processes, including cell adhesion, migration, differentiation, and tissue organization. Different isoforms of laminins exist, each with specific functions and tissue distributions.

The antibodies in the Laminin Marker panel are designed to identify specific laminin subunits in a tissue of interest to further understand the roles and expression patterns of different laminins.

The white paper explains the design, development, and validation of the laminin marker antibodies and includes one example of how to verify the subunit composition of laminins in tissue using multiplexed IHC with antibodies from the panel. 

Download our "Laminin Marker Panel" white paper:

Laminin Markers Panel