Integrins, Receptors for the Extracellular Matrix

Integrins are the principal receptors cells use to bind to the extracellular matrix. They constitute a family of transmembrane receptor proteins that play a crucial role in connecting the cytoskeleton to the extracellular matrix. This family is diverse, comprising 18 alpha and 8 beta subunits, which combine to form at least 24 distinct integrin heterodimers.

In-depth insights into the structure and function of integrins are explored in our White Paper. Additionally, the document introduces antibodies designed to specifically target various integrins, contributing to a comprehensive understanding of their roles in cellular processes.

Key markers include:

• αVβ3 (Integrin αVβ3): integrin αVβ3 is a key marker associated with cell adhesion and migration, particularly in angiogenesis and bone metabolism.
• α5β1 (Integrin α5β1): this integrin plays a crucial role in mediating cell adhesion to fibronectin, influencing processes such as cell migration and tissue repair.
• αIIbβ3 (Integrin αIIbβ3): known as a platelet-specific integrin, αIIbβ3 is vital for platelet aggregation and is a key player in hemostasis and thrombosis.
• α4β7 (Integrin α4β7): integrin α4β7 is involved in leukocyte trafficking and homing to mucosal sites, playing a significant role in the immune response.
• α6β4 (Integrin α6β4): this integrin is particularly important in epithelial tissues, contributing to cell adhesion, migration, and signaling in various physiological processes.

Download our white paper and advance your understanding of integrin functions.

Integrins, Receptors for the Extracellular Matrix