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In situ PLA - Application Example


Proteins form the foundation of cellular structure and orchestrate essential functions within living organisms. Engaging in multifaceted interactions, proteins collaborate with diverse molecules, notably with other proteins, to execute their vital roles. These protein-protein interactions underpin a spectrum of cellular processes, encompassing protein modifications, transport mechanisms, signaling cascades, and cell cycling.

The exploration of protein interactions holds paramount importance in elucidating the intricacies of protein functions within the broader context of cell biology, encompassing both normal physiological states and disease conditions.

The proximity ligation assay (PLA) is a technique designed for the in situ study of protein-protein interactions within tissues or cells. This method enables the detection, visualization, and quantification of these interactions, as well as the identification of individual proteins and protein modifications within cellular or tissue sections.

  

Anti-LMNB1 Antibody
Anti-LMNB1 Antibody

Anti-LMNB1 Antibody

AMAb91251
In Stock (10+)
4 106 kr
Anti-TP53BP1 Antibody
Anti-TP53BP1 Antibody

Anti-TP53BP1 Antibody

HPA022133
In Stock (10+)
4 352 kr
Anti-PDS5A Antibody
Anti-PDS5A Antibody

Anti-PDS5A Antibody

HPA036661
In Stock (10+)
4 352 kr
Anti-LBR Antibody
Anti-LBR Antibody

Anti-LBR Antibody

HPA049840
In Stock (10+)
4 352 kr
Anti-FTSJ3 Antibody
Anti-FTSJ3 Antibody

Anti-FTSJ3 Antibody

HPA055544
In Stock (10+)
4 352 kr
Anti-RBM25 Antibody

Anti-RBM25 Antibody

HPA070713
In Stock (10+)
4 352 kr
Anti-ACSL3 Antibody

Anti-ACSL3 Antibody

HPA071021
In Stock (10+)
4 352 kr

 

Download the "In situ PLA - Application Example" white paper.

The data presented in the white paper illustrate the application of Triple A Polyclonals and PrecisA Monoclonals for detecting protein-protein interactions within human tissues using the is-PLA technique. Utilizing such studies can significantly contribute to advancing our understanding of protein functions in both normal and pathological states.

In situ PLA - Application Example