Histones
Histones, essential proteins within chromosomes, provide crucial structural support, enabling the organization of DNA in the form of chromatin.
In eukaryotic cells, histone proteins serve as the cornerstone for storing genetic information. Chromatin, the resulting structure, is composed of tightly packed nucleosomes, where each nucleosome unit consists of an octamer featuring pairs of core histones—H3, H4, H2A, and H2B. Moreover, the linker histone H1 plays a pivotal role in connecting nucleosomes, influencing chromatin density, and contributing to its folding.
Our white paper provides a curated selection of our PrecisA Monoclonal antibodies targeting histones, validated for Immunohistochemistry (IHC), Western Blotting (WB), and Immunocytochemistry-Immunofluorescence (ICC-IF).
Our histone markers are valuable tools for researchers studying chromatin dynamics, gene regulation, and epigenetic modifications in various biological contexts.