Epithelial-to-Mesenchymal Transition Markers
The Epithelial to epithelial-to-mesenchymal transition (EMT) antibody marker panel comprises a comprehensive array of mouse monoclonals meticulously designed to target critical EMT markers associated with various cellular processes. This collection offers targeted insights into key facets of EMT, encompassing alterations in cell junctions, cytoskeletal dynamics, transcriptional regulation, and cellular migration and motility.
Within the EMT process, specific protein markers play pivotal roles in delineating the transition from an epithelial to a mesenchymal phenotype, indicative of changes in cell behavior and function.
Some noteworthy protein markers specific to the EMT include:
- E-Cadherin: E-Cadherin is a classic epithelial marker whose downregulation is a hallmark of EMT. Reduction in E-Cadherin levels contributes to the loss of cell adhesion characteristic of mesenchymal cells.
- N-Cadherin: N-Cadherin, a mesenchymal marker, is often upregulated during EMT. The switch from E-Cadherin to N-Cadherin expression is associated with increased cell motility and invasion.
- Vimentin: Vimentin is a cytoskeletal protein whose increased expression is indicative of mesenchymal transformation. It plays a role in maintaining cell structure and promoting motility.
- Snail, Slug, and Twist: These transcription factors are key regulators of EMT, orchestrating the repression of epithelial markers and induction of mesenchymal markers. Their overexpression is associated with enhanced migratory and invasive properties.
- Fibronectin: Fibronectin is an extracellular matrix protein whose upregulation is linked to the mesenchymal phenotype. It influences cell adhesion and migration during EMT.