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Polyclonal anti-ADPRHL2/ARH3 used to gain insights into chromatin regulation and human disease

Article: "Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease"


ADP-ribosylation is a reversible post-translational protein modification that regulates numerous processes, including DNA damage repair and chromatin remodeling.

ARH3/ADPRHL2 and PARG are the primary enzymes reversing ADP-ribosylation in vertebrates, yet their functions in vivo remain unclear.

Using our rabbit polyclonal anti-ADPRHL2/ARH3 (HPA027104), this study from the University of Copenhagen reports that the loss of ARH3 activity in patient-derived primary fibroblasts and glioblastoma cells results in the accumulation of ADPr, increased PARGi sensitivity, and PARPi resistance leading to highly toxicity to the cell and distinct (patho)physiological effects.

Read full article here.

Find out more about our polyclonal Anti-ADPRHL2/ARH3 (HPA027104).