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Multiplexed selectivity screening of anti-GPCR antibodies

These results provide important insights into the immunogenicity of GPCR epitopes and form a basis for designing therapeutic Abs and for detecting pathological auto-Abs against GPCRs.


The superfamily of heterotrimeric guanine-nucleotide-binding regulatory protein (G protein)–coupled receptors (GPCRs) comprises ~750 membrane proteins that mediate signaling pathways for many aspects of cellular physiology and intercellular communication.

Anti-GPCR antibodies have emerged as a key enabling tool in many bioanalytical methods to study the biology and molecular pharmacology of GPCRs.

Read how a multiplexed immunoassay helped to test over 400 anti-GPCR antibodies from the Human Protein Atlas (manufactured by Atlas Antibodies) targeting a customized library of 215 GPCRs.

Find out more about GPCR markers.