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Anti-MUC5B rabbit polyclonal in SARS-CoV-2 research

Article: "Goblet Cell Hyperplasia Increases SARS-CoV-2 Infection in Chronic Obstructive Pulmonary Disease"


SARS-CoV-2 preferentially infects goblet cells in the bronchial airway epithelium. Goblet cells are a specialized type of epithelial cell that secrete mucins (MUCs), significant mucus components.

A study by Jaspreet Osan et al. (2022) from the University of North Dakota, USA, used our anti-MUC5B rabbit polyclonal (HPA008246; dil. 1:500) in fluorescence imaging to stain the apical site of the airway epithelium.

The results reveal that goblet cells play a critical role in SARS-CoV-2-induced pathophysiology in the lung.

The image shows the immunofluorescence detection of MUC5B-positive goblet cells (anti-MUC5B, cyan) and SARS-CoV-2 N (anti-N, green); DAPI (blue). The arrows indicate SARS-CoV-2-infected nonciliated MUC5B-positive goblet cells.

Find the polyclonal Anti-MUC5B antibody used in the research.

Read full article here.