Anti-HMCES polyclonal antibody in lung adenocarcinoma study
Article: "Loss of the abasic site sensor HMCES is synthetic lethal with the activity of the APOBEC3A cytosine deaminase in cancer cells"
The capacity to repair damaged DNA may modulate individual susceptibility to develop lung cancer.
The 5-hydroxymethylcytosine binding, ESC-specific (HMCES) is the mammalian ortholog of the prokaryotic YedK protein that functions in DNA damage response. HMCES specifically enables DNA double-strand break repair.'
Using our anti-HMCES polyclonal antibody (HPA044968) in Western Blot, this study suggests that HMCES is an attractive target for selective treatment of A3A-expressing lung adenocarcinoma.
Find out more about our polyclonal antibody Anti-HMCES (HPA044968).