Atlas Antibodies Unveils Revolutionary Molecular Tool, MolBoolean™

Unlock the secrets of protein-protein interactions in cells and tissue with MolBoolean™

Following the company’s vision, in a significant leap forward for biomedical research, Atlas Antibodies has introduced its latest innovation: MolBoolean™, a groundbreaking in situ proximity technology designed to revolutionize protein analysis.

This pioneering advancement enables the simultaneous detection of both free and interacting fractions for two protein targets, promising to accelerate scientific discoveries.

 Discover the benefits of MolBoolean

Beyond Proximity Ligation

Developed after years of meticulous research and development by Atlas Antibodies' Research and Development team in collaboration with Professor Ola Söderberg from Uppsala University, MolBoolean™ represents a paradigm shift in protein analysis techniques. Unlike conventional methods, MolBoolean™ offers:

• Complete spatial quantitative analysis of protein-protein interactions by simultaneous detection of free and interacting proteins.
• Accurate quantification by normalization of interaction data to total target protein levels. 
• Biologically relevant data without the need for engineered protein expression.
• 1000-fold increased fluorescence signal by Rolling Circle Amplification, allowing detection and quantification of low abundant proteins.

“I am very proud to announce the release of MolBoolean, a cutting-edge technology developed in collaboration with leading scientists in the PLA field. This kit enables researchers to identify and measure protein-protein
interactions in situ, in both fixed cells and tissue. MolBoolean is a valuable addition to our wide range of high-quality antibodies, and we believe it will greatly benefit our customers' research”, said Ingela Hofverberg, CEO at Atlas Antibodies. 

The versatility of MolBoolean™ makes it a valuable tool for a wide range of applications, including drug discovery, biomarker identification, and understanding disease mechanisms.

“We are thrilled to introduce MolBoolean, a technology that enables researchers to extract more information from their in situ protein proximity experiments. In contrast to traditional approaches to study protein-protein (PPIs) interactions, the MolBoolean kit  provides the ability to simultaneously monitor both free and interacting fractions for two protein targets and can be applied in both fixed cells and tissue. The more comprehensive information generated by MolBoolean enables the normalization of interaction data to total target protein levels, something that is crucially important when studying a dynamic cell environment. Therefore, MolBoolean will add more confidence to the interpretation of your protein proximity data,” stated Mikael Malmqvist, PhD Principal Scientist at Atlas Antibodies.