Ion channels as promising biomarkers in cancer
The emerging role of voltage-gated ion channels in cancer has gained increasing interest in recent years, revealing how they contribute to different aspects and stages of the cancer process, including metastasis. In this blog post, we share bits of evidence about the involvement of voltage-gated ion channels in human cancers, highlighting their promising use as biomarkers.
How Enhanced Validation helps you publish your research
Do you know what to expect from a good antibody? How and when an antibody meets your expectations? Have you ever heard about enhanced validation? Read on to know more about it!
Now I see you: the imaging toolbox that improves the detection of primary ciliary dyskinesia
Ciliopathies are inherited human disorders that affect primary cilia genes. The authors of this study took part in our Explorer Program. Read on to discover what they found.
How to determine the specificity of an antibody for Western Blot
Paramount for a successful Western blot, is the ability of the primary antibody to detect the protein of interest. But how to validate an antibody for Western blot?
How to succeed with your IHC: buffers and chemicals.
Successful immunohistochemical staining requires reliable, high-quality reagents to fixate, wash, and permeabilize the tissue. But what is the rationale behind the fact that certain buffers or storage conditions are better to use than others, or is it all just empiric?
Interview with a scientist: Tissue Atlas - past, present and future challenges
The Tissue Atlas is a collection of hundreds of immunohistochemical microscopic images corresponding to tissues from most parts of the human body, showing where all human proteins are localized. Learn more.
Contribute to advancing science by publishing your negative results
Have you ever obtained an amazing result that contradicts previous theory? If all looks well in the experiment, why not trust it?
Where are your proteins? An overview using the Cell Atlas
The human body is the result of a trillion cells communicating with each other. Early biologists described cells as simple membranous sacs containing fluid and a few floating particles. Today we know that cells are infinitely more complex than that. Read here about the Cell Atlas, part of the Human Protein Atlas, for insights into the spatio-temporal distribution of proteins within human cells.
How can I stain multiple proteins in the same tissue or cell?
Multiplexing-IHC simultaneously quantifies different immune markers on individual cells within different tumor types. But how do you stain multiple proteins in the same cell or tissue?
3 steps to publishing a paper using the Tissue Atlas - a case study
In this blog, we tell you about that time when researchers interested in a new therapeutic target for patients with type 2 diabetes, knocked at our door asking for help, and how we used the Tissue Atlas to answer their questions. But let’s start from the beginning.