Cart 0

Tumor Microenvironment and Cancer Immunity

The tumor microenvironment (TME) represents the intricate milieu surrounding a tumor, comprising various cellular and non-cellular components that intricately interact with cancer cells. This dynamic and multifaceted environment exerts a profound influence on tumor progression, metastasis, and response to therapy. The TME is a complex network of immune cells, fibroblasts, blood vessels, extracellular matrix components, and signaling molecules, collectively orchestrating a supportive or inhibitory landscape for the tumor.

Within the TME, specific protein markers play crucial roles in modulating tumor behavior and are often indicative of the immune response, angiogenesis, and extracellular matrix composition.

Some notable protein markers specific to the TME include:

PD-L1 (Programmed Death-Ligand 1): PD-L1 is expressed on the surface of tumor cells and immune cells within the TME. Its interaction with PD-1 on immune cells can suppress the immune response, facilitating immune evasion by the tumor.

TGF-β (Transforming Growth Factor-beta): TGF-β is a multifunctional cytokine in the TME that regulates processes such as cell proliferation, differentiation, and immune response. Its dysregulation contributes to the immunosuppressive nature of the TME.

VEGF (Vascular Endothelial Growth Factor): VEGF is a key protein involved in angiogenesis within the TME. It promotes the formation of new blood vessels, supporting tumor growth and providing a route for metastatic spread.

Granzyme B: Granzyme B is an enzyme released by cytotoxic T cells and natural killer cells within the TME. Its presence reflects the cytotoxic activity of the immune response against tumor cells.

 

Anti-HDAC1 Antibody
Anti-HDAC1 Antibody

Anti-HDAC1 Antibody

AMAb90781
In Stock (10+)
3 490 kr
Anti-LAMP1 Antibody
Anti-LAMP1 Antibody

Anti-LAMP1 Antibody

AMAb91298
In Stock (10+)
4 106 kr
Anti-ARG1 Antibody
Anti-ARG1 Antibody

Anti-ARG1 Antibody

AMAb90545
In Stock (10+)
4 106 kr
Anti-VIM Antibody
Anti-VIM Antibody

Anti-VIM Antibody

HPA001762
In Stock (10+)
3 490 kr
Anti-CSPG4 Antibody
Anti-CSPG4 Antibody

Anti-CSPG4 Antibody

HPA002951
In Stock (10+)
4 106 kr
Anti-LAG3 Antibody
Anti-LAG3 Antibody

Anti-LAG3 Antibody

HPA013967
In Stock (10+)
4 106 kr
Anti-TOX Antibody
Anti-TOX Antibody

Anti-TOX Antibody

HPA018322
In Stock (10+)
4 106 kr
Anti-FOXP3 Antibody
Anti-FOXP3 Antibody

Anti-FOXP3 Antibody

HPA045943
In Stock (10+)
3 490 kr
Anti-NR4A1 Antibody
Anti-NR4A1 Antibody

Anti-NR4A1 Antibody

HPA059742
In Stock (10+)
4 106 kr

 

Understanding the intricate interplay between these protein markers and the TME is crucial for developing targeted therapies that aim to manipulate the tumor microenvironment to enhance anti-tumor immune responses or disrupt supportive factors for tumor growth.

Download the "Tumor Microenvironment and Cancer Immunity" white paper:

Tumor Microenvironment and Cancer Immunity