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In situ PLA - Application Example


Proteins form the foundation of cellular structure and orchestrate essential functions within living organisms. Engaging in multifaceted interactions, proteins collaborate with diverse molecules, notably with other proteins, to execute their vital roles. These protein-protein interactions underpin a spectrum of cellular processes, encompassing protein modifications, transport mechanisms, signaling cascades, and cell cycling.

The exploration of protein interactions holds paramount importance in elucidating the intricacies of protein functions within the broader context of cell biology, encompassing both normal physiological states and disease conditions.

The proximity ligation assay (PLA) is a technique designed for the in situ study of protein-protein interactions within tissues or cells. This method enables the detection, visualization, and quantification of these interactions, as well as the identification of individual proteins and protein modifications within cellular or tissue sections.

  

Anti-LMNB1 Antibody
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Anti-LMNB1 Antibody

AMAb91251
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Anti-SUN2 Antibody
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Anti-TMPO Antibody
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Anti-LYAR Antibody
Anti-LYAR Antibody

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Anti-GON7 Antibody
Anti-GON7 Antibody

Anti-GON7 Antibody

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Anti-NIN Antibody

Anti-NIN Antibody

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Download the "In situ PLA - Application Example" white paper.

The data presented in the white paper illustrate the application of Triple A Polyclonals and PrecisA Monoclonals for detecting protein-protein interactions within human tissues using the is-PLA technique. Utilizing such studies can significantly contribute to advancing our understanding of protein functions in both normal and pathological states.

In situ PLA - Application Example