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Histones

Histones, essential proteins within chromosomes, provide crucial structural support, enabling the organization of DNA in the form of chromatin.

In eukaryotic cells, histone proteins serve as the cornerstone for storing genetic information. Chromatin, the resulting structure, is composed of tightly packed nucleosomes, where each nucleosome unit consists of an octamer featuring pairs of core histones—H3, H4, H2A, and H2B. Moreover, the linker histone H1 plays a pivotal role in connecting nucleosomes, influencing chromatin density, and contributing to its folding.

Our white paper provides a curated selection of our PrecisA Monoclonal antibodies targeting histones, validated for Immunohistochemistry (IHC), Western Blotting (WB), and Immunocytochemistry-Immunofluorescence (ICC-IF).

Our histone markers are valuable tools for researchers studying chromatin dynamics, gene regulation, and epigenetic modifications in various biological contexts.

 

Anti-HIST1H3A Antibody
Anti-HIST1H3A Antibody

Anti-HIST1H3A Antibody

AMAb91332
In Stock (10+)
3 490 kr
Anti-HIST1H2AG Antibody
Anti-HIST1H2AG Antibody

Anti-HIST1H2AG Antibody

AMAb91335
In Stock (10+)
4 106 kr
Anti-H2AFX Antibody
Anti-H2AFX Antibody

Anti-H2AFX Antibody

AMAb91346
In Stock (10+)
3 490 kr
Anti-H2AFY Antibody
Anti-H2AFY Antibody

Anti-H2AFY Antibody

AMAb91347
In Stock (10+)
4 352 kr
Anti-H2AFY Antibody
Anti-H2AFY Antibody

Anti-H2AFY Antibody

AMAb91348
In Stock (10+)
4 352 kr

 

Key markers include:


  • H3K4me3 (Histone H3 Lysine 4 trimethylation): this marker signifies trimethylation of lysine 4 on histone H3 and is associated with transcriptionally active chromatin regions.
  • H3K9me3 (Histone H3 Lysine 9 trimethylation): reflecting trimethylation of lysine 9 on histone H3, this marker is commonly linked to heterochromatin formation and transcriptional repression.
  • H3K27ac (Histone H3 Lysine 27 acetylation): acetylation of lysine 27 on histone H3 is associated with active enhancers and transcriptional activation, making this marker indicative of active gene expression.
  • H4K20me3 (Histone H4 Lysine 20 trimethylation): marking trimethylation of lysine 20 on histone H4, this histone modification is often associated with transcriptional repression and maintenance of genome stability.
  • H2A.X (Histone H2A variant): this histone variant, specifically phosphorylated at serine 139 (γH2A.X), serves as a marker for DNA damage and repair, playing a critical role in maintaining genomic integrity.


Download the white paper to explore histones with precision and reliability through our antibody offerings.

Histones