Human Protein Atlas 22 - Launch webinar

AI-based efforts facilitate the mapping of the human building blocks.
The Human Protein Atlas has launched two new sections, both relying heavily on AI-based prediction modeling and machine learning.
1. Human Disease Blood Atlas
• comprehensive protein levels in blood covering 12 different cancer types
• blood protein levels using targeted proteomics and proximity extension assay
• proteins associated with each of the analyzed cancers
2. Structure Atlas
• the experimental and predicted 3D structure of human proteins
• the known missense variants with clinical significance
• the known missense variants in the population
• the antigen structure for a majority of antibodies

The recording is the property of Human Protein Atlas.

Importance of reliable antibodies in tumor pathology, focus on gynecological pathology

Immunohistochemistry (IHC) is widely used in modern anatomic pathology both for diagnostic classification of tumors and as companion diagnostic to drug treatment. In female genital tract pathology, the main categories of tumors have some distinctive IHC features, and IHC can be used to establish or confirm diagnosis. It can be particularly important for diagnosis and classification of poorly differentiated neoplasms and metastatic tumors. Highly validated, specific and sensitive primary antibodies are of crucial importance for the IHC studies.

The Human Protein Atlas project (HPA, www.proteinatlas.org) is a large-scale Swedish initiative aiming at mapping the entire human proteome in both normal and tumor tissues using antibody-based approach. Building on the heritage of the HPA, Atlas Antibodies is continuously working on development of novel monoclonal antibodies, the PrecisA Monoclonals™. A great effort is put into careful design and validation of the antibodies, which can be used for studying pathophysiological mechanisms of cancer, as well as diagnostic and prognostic markers in pathology.

Lecturer: Dr. Eugenia Kuteeva, Principal Scientist at Atlas Antibodies.

The recording is the property of Atlas Antibodies.

The Human Protein Atlas - Spatial proteomics in health and disease

In this webinar, Dr. Cecilia Lindskog discusses how spatial proteomics can contribute to further understanding of human biology.

You will learn:
• How the HPA resource can be used to study mRNA and protein expression profiles across tissues, cells, and organelles
• About the importance of stringent antibody validation for reliable protein detection
• How integration of data across platforms and technologies allows for characterizing the human building blocks at higher resolution

The webinar was hosted by Atlas Antibodies. The recording is the property of Atlas Antibodies.

The ins and outs of nucleocytoplasmic trafficking in ALS/FTD

In this webinar, Dr. Rita Sattler, Barrow Neurological Institute, discusses the latest insights into the mechanisms of dysfunctional nuclear-cytoplasmic trafficking of RNA binding proteins and how they might contribute to neurodegeneration in ALS/FTD.

The webinar was hosted by Nature Research and sponsored by Atlas Antibodies. The recording is the property of Atlas Antibodies.

Glioma Biology and Molecular Markers

Date: October 21, 2021
Speaker: Dr. Carolyn Marks, Research Scientist, Atlas Antibodies

Gliomas are heterogeneous tumors derived from glial cells and remain the deadliest form of brain cancer. This webinar features the history of glioma classification, the evolution of the molecular-based classification, and the emergence of an integrated diagnosis. Specific molecular markers are highlighted that revolutionized glioma biology and the clinical ramifications of misclassification are described. A summary of the current genetic, proteomic, and cellular biomarkers of glioma is presented. The current approaches and challenges in glioma diagnosis, therapy, and prognosis are described. Finally, existing, and upcoming proteomic resources are offered to aid in overcoming the major hurdles in glioma diagnostics and treatment today.

The webinar was hosted by American Association for Cancer Research (AACR) and sponsored by Atlas Antibodies. The recording is the property of Atlas Antibodies.

The Brain Atlas: A road map through the complex protein signature of the brain

During this webinar the speakers focused on:

• Explaining the data generation and the features of the Brain Atlas
• Discussing the process for the identification and characterization of both brains- and regional-specific proteins and how they overlap
• Understanding the different strategies for profiling proteins in the mammalian brain

This webinar was hosted by Science and sponsored by Atlas Antibodies. The recording is the property of Atlas Antibodies.

Integration of transcriptomics and antibody-based proteomicsfor cell type-specific localization
of SARS-CoV-2 related proteins

In this webinar, Dr. Cecilia Lindskog presents the cell type-specific expression of ACE2 across more than 150 different cell types corresponding to all major human tissues and organs based on stringent immunohistochemical analysis. The results are compared with different datasets both on the mRNA and protein level. She also discusses the importance of integration of transcriptomics and antibody-based proteomics in studies on SARS-CoV-2 host cell entry, in order to understand the biology of the disease and to aid in the development of effective treatments to the viral infection.

The webinar was hosted by Atlas Antibodies. The recording is the property of Atlas Antibodies.